A Novel Azaphilone Muyophilone A From the Endophytic Fungus Muyocopron laterale 0307-2

Autor:	Hua-Jie Zhu, Zhunian Wang, Yu-Hua Guo, Gang Li, Longfei Li, Chao Yuan, Ke Wang
Rok vydání:	2021
Předmět:	Circular dichroism biology Chemistry Stereochemistry endophytes Trimer VCD General Chemistry Nuclear magnetic resonance spectroscopy Endophytic fungus biology.organism_classification azaphilones Muyocopron Vibrational circular dichroism ECD QD1-999 muyocopron Single crystal Original Research
Zdroj:	Frontiers in Chemistry Frontiers in Chemistry, Vol 9 (2021)
ISSN:	2296-2646
DOI:	10.3389/fchem.2021.734822
Popis:	Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid (1) and austdiol (2), and their novel heterotrimer, muyophilone A (3), were isolated and identified from an endophytic fungus, Muyocopron laterale 0307-2. Their structures and stereochemistry were established by extensive spectroscopic analyses including HRMS, NMR spectroscopy, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectroscopic methods, as well as single crystal X-ray diffraction. In the structure of 3, two compound 2-derived azaphilone units were connected through an unprecedented five-membered carbon bridge which was proposed to be originated from compound 1. Compound 3 represents the first example of azaphilone heterotrimers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1369108fc539f85d144862336b872647 https://doi.org/10.3389/fchem.2021.734822 Zobrazit plný text záznamu