The protective effect of propylthiouracil against hepatotoxicity induced by chromium in adult mice
| Autor: | Najiba Zeghal, Tahia Boudawara, Fatma Ben Hamida, Afef Troudi, Madiha Sefi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Chromium 0301 basic medicine Health Toxicology and Mutagenesis Ascorbic Acid Toxicology medicine.disease_cause Antioxidants Mice chemistry.chemical_compound Malondialdehyde Potassium dichromate chemistry.chemical_classification biology Glutathione peroxidase Alanine Transaminase Catalase Glutathione Cholesterol Liver Biochemistry Toxicity Female Chemical and Drug Induced Liver Injury medicine.medical_specialty Injections Intramuscular Superoxide dismutase 03 medical and health sciences Internal medicine medicine Animals Aspartate Aminotransferases Serum Albumin Triglycerides Glutathione Peroxidase Dose-Response Relationship Drug L-Lactate Dehydrogenase Vitamin C Superoxide Dismutase Drinking Water Public Health Environmental and Occupational Health Bilirubin Oxidative Stress 030104 developmental biology Endocrinology chemistry Propylthiouracil biology.protein Potassium Dichromate Biomarkers Oxidative stress |
| Zdroj: | Toxicology and Industrial Health. 32:235-245 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233713498446 |
| Popis: | Environmental and occupational exposure to chromium compounds, especially hexavalent chromium (Cr(VI)), is widely recognized as potentially hepatotoxic in humans and animals. Its toxicity is associated with overproduction of free radicals, which induces oxidative damage. This study focused on the possible protective effect of propylthiouracil (PTU) against potassium dichromate (K2Cr2O7). Female mice were divided into four groups (groups I–IV) with seven animals in each group. Group I served as a control, which received tap water; group II received K2Cr2O7 alone (75 mg kg−1 body weight (b.w.)) via drinking water; group III received both K2Cr2O7 via drinking water and PTU by intramuscular injection at a dose 2.5 mg/100 g−1 b.w. twice a week, and group IV received PTU alone twice a week for 30 days. Exposure of mice to Cr promoted oxidative stress with an increase in malondialdehyde, protein carbonyl, and advanced oxidation protein product levels. Nonenzymatic antioxidants such as glutathione, nonprotein thiol, vitamin C levels and enzymatic antioxidant activities such as glutathione peroxidase and superoxide dismutase were decreased, while catalase activity was increased. Biomarkers of liver injury such as aspartate and alanine transaminases, lactate dehydrogenase activities, bilirubin, albumin, and glucose levels were increased, while triglyceride and cholesterol levels decreased. Coadministration of PTU restored the above-mentioned parameters to near-normal values. The histological findings confirmed the biochemical results. |
| Databáze: | OpenAIRE |
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