Glucagon Shows Higher Sensitivity than Insulin to Grapeseed Proanthocyanidin Extract (GSPE) Treatment in Cafeteria-Fed Rats

Autor: Iris Ginés, MTeresa Blay, Carme Grau-Bové, Montserrat Pinent, Ximena Terra, Raúl Beltrán-Debón, Anna Ardévol
Rok vydání: 2021
Předmět:
0301 basic medicine
medicine.medical_specialty
endocrine system
medicine.medical_treatment
Receptor expression
030209 endocrinology & metabolism
Cafeteria
lcsh:TX341-641
GLP-1 receptor
Glucagon
Glucagon-Like Peptide-1 Receptor
Article
03 medical and health sciences
Islets of Langerhans
0302 clinical medicine
insulin/glucagon
cafeteria diet
Glucagon-Like Peptide 1
Internal medicine
medicine
Endocrine system
Animals
Insulin
Proanthocyanidins
Rats
Wistar
Glucagon-like peptide 1 receptor
Nutrition and Dietetics
biology
Grape Seed Extract
business.industry
digestive
oral
and skin physiology
Metabolism
biology.organism_classification
Rats
030104 developmental biology
medicine.anatomical_structure
Endocrinology
procyanidin
Pancreas
business
GLP1
lcsh:Nutrition. Foods and food supply
hormones
hormone substitutes
and hormone antagonists
Food Science
Zdroj: Nutrients
Nutrients, Vol 13, Iss 1084, p 1084 (2021)
Volume 13
Issue 4
ISSN: 2072-6643
Popis: The endocrine pancreas plays a key role in metabolism. Procyanidins (GSPE) targets β-cells and glucagon-like peptide-1 (GLP-1)-producing cells
however, there is no information on the effects of GSPE on glucagon. We performed GSPE preventive treatments administered to Wistar rats before or at the same time as they were fed a cafeteria diet during 12 or 17 weeks. We then measured the pancreatic function and GLP-1 production. We found that glucagonemia remains modified by GSPE pre-treatment several weeks after the treatment has finished. The animals showed a higher GLP-1 response to glucose stimulation, together with a trend towards a higher GLP-1 receptor expression in the pancreas. When the GSPE treatment was administered every second week, the endocrine pancreas behaved differently. We show here that glucagon is a more sensitive parameter than insulin to GSPE treatments, with a secretion that is highly linked to GLP-1 ileal functionality and dependent on the type of treatment.
Databáze: OpenAIRE
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