Population-based study of breast cancer survival in Cote d'Or (France): prognostic factors and relative survival
| Autor: | G. Chaplain, P. Roignot, T. Altwegg, Tienhan Sandrine Dabakuyo, Franck Bonnetain, G. Hedelin, Marie-Laure Poillot, Patrick Arveux |
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| Rok vydání: | 2007 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Population Breast Neoplasms Risk Assessment Disease-Free Survival Breast cancer Age Distribution Internal medicine Cause of Death Epidemiology medicine Humans Stage (cooking) education Aged Neoplasm Staging Probability Proportional Hazards Models Gynecology Aged 80 and over education.field_of_study Relative survival business.industry Carcinoma Ductal Breast Cancer Hematology Progesterone Receptor Status Middle Aged medicine.disease Prognosis Combined Modality Therapy Survival Analysis Log-rank test Cross-Sectional Studies Multivariate Analysis Female France business |
| Zdroj: | Annals of oncology : official journal of the European Society for Medical Oncology. 19(2) |
| ISSN: | 1569-8041 |
| Popis: | Background Few population-based studies have reported jointly analyses of relative survival according to the following prognostic factors: tumour–node–metastasis (TNM) stage, age, number of examined and positive nodes, hormonal status, histological Scarff, Bloom and Richardson (SBR) grade, tumour extension, hormone receptor status and tumour multifocal status. Patients and methods Data on female invasive breast cancer were provided by the Cote d’Or breast cancer registry. The Kaplan–Meier method and log-rank test were used to estimate and compare the survival probability at 1, 5, 10 and 15 years. The effect of prognostic factors on survival was assessed with crude and relative multivariate survival analyses. Results Crude survival seemed to be worse in patients aged >60 years compared with those aged 45–60 (P > 0.0001), whereas relative survival did not differ. TNM stage, histological SBR grade, progesterone receptor status, tumour multifocal status, locoregional extension and the period of diagnosis were independent prognostic factors of crude and relative survival. Conclusion Breast cancer is influenced by many factors. Despite the absence of any association between the number of examined nodes and overall survival in this study, the number of nodes removed, in conjunction with other prognostic factors, may be useful in selecting node-negative patients for systemic therapy. |
| Databáze: | OpenAIRE |
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