Claudin-7 expression in hepatocellular carcinoma
| Autor: | Susanne Beckebaum, Vito R. Cicinnati, M. Daoudaki, Eirini I. Brokalaki, Georgios C. Sotiropoulos, Frank Weber |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Liver tumor Cirrhosis Carcinoma Hepatocellular medicine.medical_treatment Medizin Kaplan-Meier Estimate Liver transplantation Biology Metastasis medicine Biomarkers Tumor Hepatectomy Humans RNA Messenger Claudin Survival analysis Aged Transplantation Analysis of Variance Chi-Square Distribution Tight junction Liver Neoplasms Middle Aged medicine.disease digestive system diseases Liver Transplantation Up-Regulation Gene Expression Regulation Neoplastic Treatment Outcome Hepatocellular carcinoma Claudins Surgery Female |
| Zdroj: | Transplantation proceedings. 44(9) |
| ISSN: | 1873-2623 |
| Popis: | Background The importance of adhesion molecules for local invasion by neoplastic cells and development of metastasis has been confirmed by numerous studies over the past decade. Claudins are integral parts of tight junctions. The aim of the present study was to examine the significance of the expression of claudin-7 messenger RNA (mRNA) as a prognostic factor for hepatocellular carcinoma (HCC). Patients and Methods We examined liver tumor and nontumor tissues from 20 HCC patients who underwent resection or liver transplantation. Results A significant increase in the expression of claudin-7 was observed in tumor versus nontumor tissues. There was no significant correlation between the expression profile of claudin-7 mRNA and patient demographic data, the presence of cirrhosis, or the histological stage of tumor differentiation or vascular invasion. Survival analysis showed a trend toward a better prognosis among patients with overexpression of claudin-7 in tumor tissues. |
| Databáze: | OpenAIRE |
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