Biological aspects of chondrosarcoma: Leaps and hurdles
| Autor: | Benoîte Méry, Nicolas Magné, Alexis Vallard, Sophie Espenel, Chloé Rancoule, Marie-Thérèse Aloy, Claire Rodriguez-Lafrasse, Jean-Baptiste Guy |
|---|---|
| Přispěvatelé: | Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Chondrosarcoma Bone Neoplasms Targeted therapy Phosphatidylinositol 3-Kinases 03 medical and health sciences Therapeutic approach 0302 clinical medicine Radioresistance medicine Humans Molecular Targeted Therapy Protein kinase B PI3K/AKT/mTOR pathway [PHYS]Physics [physics] business.industry TOR Serine-Threonine Kinases Therapies Investigational Drugs Investigational Hematology medicine.disease 3. Good health 030104 developmental biology Oncology Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer research Signal transduction business Proto-Oncogene Proteins c-akt LEAPS Signal Transduction |
| Zdroj: | Crit.Rev.Oncol.Hematol. Crit.Rev.Oncol.Hematol., 2018, 126, pp.32-36. ⟨10.1016/j.critrevonc.2018.03.009⟩ |
| ISSN: | 1040-8428 |
| DOI: | 10.1016/j.critrevonc.2018.03.009 |
| Popis: | International audience; Chondrosarcomas are characterized by their chemo- and radioresistance leading to a therapeutic surgical approach which remains the only available treatment with a 10-year survival between 30% and 80% depending on the grade. Non-surgical treatments are under investigation and rely on an accurate biological understanding of drug resistance mechanisms. Novel targeted therapy which represents a new relevant therapeutic approach will open new treatment options by targeting several pathways responsible for processes of proliferation and invasion. Survival pathways such as PI3K, AKT, mTOR and VEGF have been shown to be involved in proliferation of chondrosarcoma cells and antiapoptotic proteins may also play a relevant role. Other proteins such as p53 or COX2 have been identified as potential new targets. This review provides an insight into the biological substantial treatment challenges of CHS and focuses on improving our understanding of CH biology through an overview of major signaling pathways that could represent targets for new therapeutic approaches. |
| Databáze: | OpenAIRE |
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