Anti-Müllerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH
| Autor: | Hélène Bry-Gauillard, Florence Larrat-Ledoux, Isabelle Beau, Luigi Maione, Jean-Marc Levaillant, Janet E. Hall, Sylvie Brailly-Tabard, Philippe Chanson, Jacques Young, Nathalie Massin, Nadine Binart |
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| Rok vydání: | 2017 |
| Předmět: |
Anti-Mullerian Hormone
endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Biochemistry 0302 clinical medicine Endocrinology education.field_of_study 030219 obstetrics & reproductive medicine biology Anti-Müllerian hormone Organ Size Recombinant Proteins female genital diseases and pregnancy complications medicine.anatomical_structure Female Follicle Stimulating Hormone Human Luteinizing hormone hormones hormone substitutes and hormone antagonists Adult Isolated hypogonadotropic hypogonadism endocrine system medicine.medical_specialty Hormone Replacement Therapy Population 030209 endocrinology & metabolism Young Adult 03 medical and health sciences Ovulation Induction Hypogonadotropic hypogonadism Internal medicine medicine Humans Ovarian follicle education business.industry Hypogonadism Ovary Biochemistry (medical) Kallmann Syndrome Luteinizing Hormone medicine.disease Antral follicle body regions Case-Control Studies biology.protein Ovulation induction business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 102:1102-1111 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Context Isolated hypogonadotropic hypogonadism (IHH), characterized by gonadotropin deficiency and absent puberty, is very rare in women. IHH prevents pubertal ovarian stimulation, but anti-Mullerian hormone (AMH) and antral follicle count (AFC) have not been studied. Objectives (1) To compare, in IHH vs controls, AMH, ovarian volume (OV), and AFC. (2) To compare, in IHH, ovarian responses to recombinant human follicle-stimulating hormone (rhFSH) and rhFSH plus recombinant human luteinizing hormone (rhLH). Subjects Sixty-eight IHH women; 51 matched healthy women. Methods Serum LH, FSH, sex steroids, inhibin B (InhB), AMH, and OV and AFC (sonography) were compared. Ovarian response during rhFSH administration was assessed in 12 IHH women with low AMH levels and low AFC and compared with hormonal changes observed in six additional IHH women receiving rhFSH plus rhLH. Results InhB was lower in IHH than in controls. AMH levels were also significantly lower in the patients, but two-thirds had normal values. Mean OV and total, larger, and smaller AFCs were lower in IHH than in controls. Ovarian stimulation by rhFSH led to a significant increase in serum estradiol and InhB levels and in the number of larger antral follicles. AMH and smaller AFC increased early during rhFSH stimulation but then declined despite continued stimulation. rhFSH plus rhLH stimulation led to a significantly higher increase in estradiol levels but to similar changes in circulating InhB and AMH than with rhFSH alone. Conclusions IHH women have both low AMH levels and low AFC. However, their decrease can be reversed by follicle-stimulating hormone. Serum AMH and AFC should not serve as prognostic markers of fertility in this population. |
| Databáze: | OpenAIRE |
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