Propionibacterium acnes strain populations in the human skin microbiome associated with acne
| Autor: | Jenny Kim, Huiying Li, Lin Nguyen, Minghsun Liu, Marie C. Erfe, Robert L. Modlin, Jeff F. Miller, Anya Loncaric, David Elashoff, Shuta Tomida, Sorel Fitz-Gibbon, George M. Weinstock, Erica Sodergren, Bor Han Chiu, Noah Craft, Christine Du |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Human skin Biochemistry 2.2 Factors relating to physical environment Ribotyping 030207 dermatology & venereal diseases 0302 clinical medicine Acne Vulgaris 2.2 Factors relating to the physical environment 2.1 Biological and endogenous factors Aetiology Acne Skin 0303 health sciences education.field_of_study biology Human microbiome Bacterial Genomics RNA Bacterial Female Infection Biotechnology Adult DNA Bacterial Population Clinical Sciences Oncology and Carcinogenesis Virulence Dermatology Article Microbiology 03 medical and health sciences Propionibacterium acnes Sebaceous Glands Young Adult Clinical Research medicine Genetics Humans Microbiome education Molecular Biology Gram-Positive Bacterial Infections 030304 developmental biology Ribosomal Dermatology & Venereal Diseases Human Genome Cell Biology DNA biology.organism_classification medicine.disease Metagenomics RNA Ribosomal RNA Metagenome |
| Zdroj: | The Journal of investigative dermatology, vol 133, iss 9 Fitz-Gibbon, S; Tomida, S; Chiu, B-H; Nguyen, L; Du, C; Liu, M; et al.(2013). Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with Acne. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 133(9), 2152-2160. doi: 10.1038/jid.2013.21. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2dr3m8zc The Journal of investigative dermatology |
| ISSN: | 1523-1747 |
| DOI: | 10.1038/jid.2013.21. |
| Popis: | The human skin microbiome has important roles in skin health and disease. However, bacterial population structure and diversity at the strain level is poorly understood. We compared the skin microbiome at the strain level and genome level of Propionibacterium acnes, a dominant skin commensal, between 49 acne patients and 52 healthy individuals by sampling the pilosebaceous units on their noses. Metagenomic analysis demonstrated that although the relative abundances of P. acnes were similar, the strain population structures were significantly different in the two cohorts. Certain strains were highly associated with acne, and other strains were enriched in healthy skin. By sequencing 66 previously unreported P. acnes strains and comparing 71 P. acnes genomes, we identified potential genetic determinants of various P. acnes strains in association with acne or health. Our analysis suggests that acquired DNA sequences and bacterial immune elements may have roles in determining virulence properties of P. acnes strains, and some could be future targets for therapeutic interventions. This study demonstrates a previously unreported paradigm of commensal strain populations that could explain the pathogenesis of human diseases. It underscores the importance of strain-level analysis of the human microbiome to define the role of commensals in health and disease. |
| Databáze: | OpenAIRE |
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