Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide)
| Autor: | Jakob Dahlin, Annarita Antelmi, Cecilia Svedman, Nils Hamnerius, Tina Lejding, Ann Pontén, Inese Dubnika Hauksson, Thanisorn Sukakul, Marléne Isaksson, Magnus Bruze |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class prevalence Biguanides Dermatology medicine.disease_cause 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Allergen preservative Retrospective analysis medicine Humans Immunology and Allergy 030212 general & internal medicine Allergic contact dermatitis Aged Retrospective Studies Sweden Polyaminopropyl biguanide Molecular Structure polyhexamethylene biguanide cosmetics Biguanide business.industry Preservatives Pharmaceutical Patch test polyaminopropyl biguanide Original Articles Middle Aged Patch Tests medicine.disease chemistry Contact allergy Concomitant Dermatitis Allergic Contact Female Original Article allergic contact dermatitis business patch test |
| Zdroj: | Contact Dermatitis |
| ISSN: | 1600-0536 0105-1873 |
| Popis: | Background: Polyaminopropyl biguanide (INCI name) and polyhexamethylene biguanide (PHMB) are polymeric biguanides. PHMB is a broad-spectrum antimicrobial substance used as a preservative in many products. Due to our limited knowledge on PHMB contact allergy frequency and the fact that cases of allergic contact dermatitis to PHMB might be missed, we have included PHMB as a screening allergen since 2016. Objective: To report the prevalence of positive patch-test reactions to PHMB as a screening allergen in patients with suspected allergic contact dermatitis. Methods: A retrospective analysis of 1760 patch tested patients from July 2016 to December 2018 was performed. Polyaminopropyl biguanide 2.0% aqua was included in the extended Malmo baseline series during the study period. Results: Of all patients, 1204 (68.4%) were female. Positive patch-test reactions were reported in 19 patients (1.1%). The most common sites of lesions were face, head, and neck (52.6%). There was a significant correlation between concomitant reactions to PHMB and other cosmetic-related allergens. Conclusion: The prevalence of positive reactions to PHMB was higher than that previously reported. Patch testing with PHMB should be performed in patient with dermatitis who have lesions on the face, head, and neck. (Less) |
| Databáze: | OpenAIRE |
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