Polyunsaturated fatty acids and type 2 diabetes: Impact on the glycemic control mechanism
| Autor: | Olívia Gonçalves Leão Coelho, Bárbara Pereira da Silva, Rita de Cássia Gonçalves Alfenas, Lílian Lelis Lopes, Daniela Mayumi Usuda Prado Rocha |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Blood Glucose medicine.medical_specialty 030209 endocrinology & metabolism Type 2 diabetes Carbohydrate metabolism Industrial and Manufacturing Engineering 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Fatty Acids Omega-3 Medicine Humans Glycemic chemistry.chemical_classification 030109 nutrition & dietetics business.industry Mechanism (biology) Type 2 Diabetes Mellitus General Medicine Fasting medicine.disease Alternative treatment Endocrinology chemistry Diabetes Mellitus Type 2 Fatty Acids Unsaturated business Food Science Polyunsaturated fatty acid |
| Zdroj: | Critical reviews in food science and nutrition. 57(17) |
| ISSN: | 1549-7852 |
| Popis: | There is a growing mortality related to co-morbidities associated with diabetes mellitus. Intake of polyunsaturated fatty acids (PUFA) has been associated with low cardiometabolic risk and reduction of inflammatory process. The objective of this paper is to review the impact of PUFA intake on glycemic control in diabetic patients as well as to elucidate the possible mechanisms involved. Medline/PubMed electronic database was searched to identify studies published within last five years regarding the effect of PUFA intake on glucose metabolism in type 2 diabetics. The search terms used were "polyunsaturated fatty acid(s)," "PUFA," and "diabetes." We included only interventional studies that assessed the effects of PUFA intake on glucose metabolism - fasting glucose, serum insulin, HbA1c, and HOMA-IR assessment- in type 2 diabetics. Initially, 48 articles were identified, of which one was not available and 41 did not match the inclusion criteria. Within the selected studies, three articles showed an improvement in fasting blood glucose, two showed an increase in fasting glycemia, and there was no effect of intervention in one article only. Based on the analyzed clinical interventional studies, supplementation of 0.42-5.2-g PUFA/day for at least eight weeks may become an alternative treatment for type 2 diabetes mellitus, particularly in Asian subjects. |
| Databáze: | OpenAIRE |
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