Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain
| Autor: | Atsushi Yamaguchi, Kohji Sato, Noriaki Mitsuda, Osamu Hori, Yoshikuni Kawai, Emiko Senba, Toshihide Yamashita, Manabu Taniguchi, Shin-ichi Miyake, Michio Tamatani, Masaya Tohyama |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Citric Acid Cycle Central nervous system Mitochondrion Biology Kidney Tricarboxylate Rats Sprague-Dawley Cellular and Molecular Neuroscience Gene expression medicine Animals RNA Messenger Inner mitochondrial membrane Molecular Biology Neurons Messenger RNA Brain Intracellular Membranes Immunohistochemistry Mitochondria Rats Olfactory bulb Cell biology medicine.anatomical_structure Gene Expression Regulation Liver nervous system Biochemistry Carrier Proteins Energy Metabolism Phosphoenolpyruvate carboxykinase Spleen |
| Zdroj: | Molecular Brain Research. 100:67-73 |
| ISSN: | 0169-328X |
| DOI: | 10.1016/s0169-328x(02)00139-0 |
| Popis: | The tricarboxylate carrier protein catalyzes an electroneutral exchange across the mitochondrial inner membrane of tricarboxylate, dicarboxylate or phosphoenolpyruvate. We examined expression and localization of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain. TCC mRNA was ubiquitously expressed in all rat tissues examined and was abundant in brain, liver and kidney. TCC protein as well as mRNA was widely expressed in brain, and the protein expression was strong in neuronal cells in the hippocampus, the olfactory bulb, the corpus mamillare and the cerebellum. Our results suggest that this tricarboxylate carrier protein may contribute to biosynthesis and bioenergetics in neuronal cells in brain. |
| Databáze: | OpenAIRE |
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