Epidermal growth factor receptor (EGFR), proliferating cell nuclear antigen (PCNA) and Ki-67 antigen in laryngeal epithelial lesions
| Autor: | Michał Jeleń, Joanna Jelen-Krzeszewska, Maria Zalesska-Krecicka, Tomasz Krecicki, Jerzy Rak, Teresa Szkudlarek |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Biology Epidermal growth factor Proliferating Cell Nuclear Antigen medicine Carcinoma Humans Laryngeal Neoplasms Neoplasm Staging Hyperplasia Staining and Labeling Laryngeal Neoplasm Middle Aged medicine.disease Immunohistochemistry Proliferating cell nuclear antigen ErbB Receptors Ki-67 Antigen Oncology Epidermoid carcinoma Ki-67 biology.protein Carcinoma Squamous Cell Female Oral Surgery Immunostaining |
| Zdroj: | Oral oncology. 35(2) |
| ISSN: | 1368-8375 |
| Popis: | The epidermal growth factor receptor (EGFR), proliferating cell nuclear antigen (PCNA) and Ki-67 immunostaining in paraffin sections from 154 cases of laryngeal squamous cell carcinoma, 25 specimens of normal and hyperplastic laryngeal epithelium, and 21 preneoplastic lesions was examined. The difference of EGFR expression and PCNA score between laryngeal cancer and dysplastic lesions vs normal and hyperplastic epithelium was significant. There was significant difference in Ki-67 score between malignant vs premalignant lesions and normal and hyperplastic epithelium. There was significant correlation between PCNA score and histopathological grading of the tumour. The highest PCNA expression was detected in stage G3. Our findings have shown that PCNA and Ki-67 staining can be used as a marker of cell proliferative activity in laryngeal epithelial lesions. EGFR, PCNA and Ki-67 expression correlate with severity of laryngeal lesions. PCNA immunostaining can aid in estimating the histological grade of malignant lesions. |
| Databáze: | OpenAIRE |
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