MSH6 gene pathogenic variant identified in familial pancreatic cancer in the absence of colon cancer
| Autor: | Dejan Lazarevic, Pier Alberto Testoni, Annalisa Russo Raucci, Giovanni Tonon, Paola Carrera, Raffaella Alessia Zuppardo, Maria Grazia Patricelli, Giulia Martina Cavestro, Francesca Giannese, Maurizio Ferrari, Alessandro Mannucci, F Calabrese, Stefano Crippa |
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| Přispěvatelé: | Mannucci, A., Zuppardo, R. A., Crippa, S., Carrera, P., Patricelli, M. G., Russo Raucci, A., Calabrese, F., Lazarevic, D., Giannese, F., Tonon, G., Ferrari, M., Testoni, P. A., Cavestro, G. M. |
| Rok vydání: | 2020 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Colorectal cancer pancreatic cancer colorectal cancer familial pancreatic cancer Adenocarcinoma 03 medical and health sciences 0302 clinical medicine Pancreatic cancer medicine Humans Hepatology business.industry Endometrial cancer hereditary pancreatic cancer Gastroenterology nutritional and metabolic diseases Cancer MSH6 medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis Penetrance digestive system diseases Lynch syndrome DNA-Binding Proteins Pancreatic Neoplasms mismatch repair 030220 oncology & carcinogenesis Colonic Neoplasms Cancer research 030211 gastroenterology & hepatology business |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 32:345-349 |
| ISSN: | 0954-691X |
| Popis: | Objectives Lynch syndrome is characterized by pathogenetic variants in the mismatch repair genes and autosomal dominant inheritance with incomplete penetrance. Lynch syndrome is characterized by colorectal and, with lesser and variable extent, extracolonic cancers. We describe a family with MSH6-dependent Lynch syndrome and familial pancreatic cancer and other tumours (gastric and endometrial), in the absence of colorectal neoplasia. Methods Patients were analysed by sequencing, Next Generation or Sanger, to identify germinal pathogenic variants in hereditary cancer genes. Results We identified the MSH6 gene pathogenic variant c.2194C>T, p.(Arg732Ter) in a family with hereditary pancreatic cancer without diagnosed cases of colorectal adenocarcinoma. Seven family members were affected by the MSH6 pathogenic variant. Three had pancreatic adenocarcinoma at 65, 57 and 44 years; one had endometrial cancer at 36 years. None of the remaining three subjects (75, 45 and 17 years old) had developed any cancer yet. Conclusions Lynch syndrome should be suspected in families with familial pancreatic cancer, even in the absence of colon cancers. Specifically, our observation supports the association between the MSH6 c.2194C>T pathogenic variant and extracolonic tumours and it suggests that MSH6 pathogenic variants are associated with familial pancreatic cancer more frequently than assumed. |
| Databáze: | OpenAIRE |
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