Molecular characterization of HLA class II genes in celiac disease patients of Latin American Caucasian origin
| Autor: | M. L. Satz, Leonardo Fainboim, Augustovski F, Chertkoff L, G. Theiler, Cowan Ep, Herrera M, DeRosa S |
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| Rok vydání: | 1994 |
| Předmět: |
musculoskeletal diseases
Heterozygote endocrine system diseases Immunology Population Molecular Sequence Data Argentina Immunogenetics Biology Biochemistry HLA-DR5 Antigen DNA sequencing White People Exon immune system diseases HLA-DQ Antigens Genetics Immunology and Allergy Humans Amino Acid Sequence Allele skin and connective tissue diseases education Child Gene Alleles education.field_of_study HLA-DQ Antigen Haplotype Histocompatibility Antigens Class II nutritional and metabolic diseases General Medicine DNA Exons Celiac Disease |
| Zdroj: | Tissue antigens. 43(2) |
| ISSN: | 0001-2815 |
| Popis: | In the present study, the polymorphic domain of HLA class II genes present in a pediatric population of Argentinian celiac disease patients was analyzed by hybridization to sequence-specific oligonucleotides and DNA sequencing. Sixteen out of 16 DR5/7 heterozygous patients bore the DQA1*0501 and DQB1*0201 alleles implicated in the DQ2 risk specificity. The second exon of DQA1, DQB1 and DRB1 genes from 2 DR5/7 patients was characterized by DNA sequencing. The following alleles were found in both patients: DRB1*1101 and DRB1*0701; DQB1*0301 and DQB1*0201; DQA1*0501 and DQA1*0201. Previous serological analysis in this population had shown the presence of DQ2 in 95% of the patients (40% in controls) and a negative association with DQ1 haplotypes, suggesting the presence of other "permissive" or neutral alleles. The following HLA-DQB1 alleles, besides DQB1*0201, were identified in 31 CD patients: DQB1*0301, 0302, 0401 and 0402. All these alleles share a common pattern of residues between positions 84 and 90, and distinct from that present in DQ1-related alleles. |
| Databáze: | OpenAIRE |
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