Hyperphagia in short bowel patients: Fat-free mass is a strong predictor
| Autor: | Cécile Bétry, S. Ait, Cécile Chambrier, M. Lauverjat, Thomas Mouillot, C. Bergoin, D. Barnoud |
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| Přispěvatelé: | Hospices Civils de Lyon (HCL), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon) |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Short Bowel Syndrome medicine.medical_specialty Endocrinology Diabetes and Metabolism [SDV]Life Sciences [q-bio] Nutritional Status 030209 endocrinology & metabolism Hyperphagia Gastroenterology Intestinal absorption Cohort Studies 03 medical and health sciences 0302 clinical medicine Absorptiometry Photon Fat free mass Internal medicine Medicine Humans Resting energy expenditure Aged 2. Zero hunger 030109 nutrition & dietetics Nutrition and Dietetics Hand Strength business.industry Anthropometry Middle Aged Short bowel syndrome medicine.disease Parenteral nutrition Intestinal Absorption Cohort Body Composition Female business Energy Intake Hormone |
| Zdroj: | Nutrition Nutrition, Elsevier, 2019, 62, pp.146-151. ⟨10.1016/j.nut.2018.12.013⟩ |
| ISSN: | 1873-1244 0899-9007 |
| Popis: | Objectives Some patients with short bowel syndrome (SBS) develop hyperphagic behavior. Such an increase in food intake stimulates intestinal adaptation and limits dependence on parenteral nutrition (PN). The aim of this study was to determine the factors modulating food consumption in patients with SBS. Methods The associations between oral energy intake (OEI) and anthropometric, metabolic, nutritional, and intestinal absorption–related characteristics were determined in a monocentric cohort of patients with SBS on PN with a stable nutritional status. Body composition was assessed by dual x-ray absorptiometry. Data were retrospectively collected from clinical records. Results After screening, 38 adult patients with a SBS on PN were included in this study. OEI ranged from 577 to 4054kcal/d. OEI correlated positively with weight, fat-free mass, handgrip strength, and resting energy expenditure (REE) and negatively with free triiodothyronine and C-reactive protein using Spearman correlation. Fat-free mass and thyroid-stimulating hormone remained positively correlated with OEI independently of all other parameters in a multilinear regression model. Conclusions Fat-free mass is a strong predictor of OEI in patients with SBS on PN and without debilitating gastrointestinal symptoms. Increasing fat-free mass could be a way to stimulate OEI in these patients. Further studies are needed to assess this assumption. |
| Databáze: | OpenAIRE |
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