The lymphocyte: monocyte ratio: B- and T-cell ratio after radiotherapy, chemotherapy and surgery
| Autor: | G.Rossall H Sealy, Elaine Lynette Wilson, David Beatty, Ben Smit, M. Betty Bennett, Peter Jacobs, Jan Stjernswärd, Eugene B. Dowdle |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Cancer Research
medicine.medical_specialty Cyclophosphamide medicine.medical_treatment Lymphocyte T-Lymphocytes Uterine Cervical Neoplasms Breast Neoplasms Monocytes Leukocyte Count White blood cell Lymphopenia Medicine Humans Radiology Nuclear Medicine and imaging Lymphocytes Chemotherapy B-Lymphocytes Radiation Leukopenia business.industry Monocyte Surgery Radiation therapy medicine.anatomical_structure Cell killing Oncology Female medicine.symptom business medicine.drug |
| Zdroj: | International journal of radiation oncology, biology, physics. 5(10) |
| ISSN: | 0360-3016 |
| Popis: | Differential white blood cell counts were taken from 42 previously untreated patients with mammary carcinoma who received radiotherapy, 10 patients with Stage III mammary carcinoma who received chemotherapy, 19 patients previously treated by a simple mastectomy, and 42 untreated patients. The percentage of B- and T-cells in the peripheral blood also was measured. Severe lymphopenia was seen in patients treated with radiotherapy and chemotherapy. The percentage of B- and T-cells remained constant before and after radiotherapy, and there was no selective depression of T-cells. The monocyte count, 3 months after radiotherapy, was significantly higher than the pre-treatment mean count. The percentage of B- and T-cells in the peripheral blood remained unchanged before and after treatment with chemotherapy. The mean lymphocyte counts following surgery were slightly higher than the control values whereas the monocyte counts were slightly lower than the control values. Surgery did not appear to influence the percentages of B- and T-cells in the peripheral blood. |
| Databáze: | OpenAIRE |
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