Effects of hyperbaric oxygen preservation on rat limb replantation: a preliminary report
| Autor: | Michael J. Im, Richard J. Edwards, John E. Hoopes |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment chemistry.chemical_element Hindlimb Creatine Oxygen chemistry.chemical_compound Gastrocnemius muscle medicine Animals Hyperbaric Oxygenation Wound Healing Glycogen business.industry Muscles Rats Inbred Strains Surgery Rats chemistry Amputation Anesthesia Replantation Room air distribution Tissue Preservation business |
| Zdroj: | Annals of plastic surgery. 27(1) |
| ISSN: | 0148-7043 |
| Popis: | The effect of hyperbaric oxygen, administered during storage, on the survival of replanted limbs was evaluated in rats. The right hindlimbs of male Sprague-Dawley rats were severed and were replanted by microvascular anastomoses after storage in either room air or hyperbaric oxygen (100% oxygen at 2.9 atm absolute) at 23 degrees C for 5 hours. The administration of hyperbaric oxygen during storage improved limb survival from 50% in the room-air, control rats to 100% (p less than 0.05). The gastrocnemius muscle of limbs treated with hyperbaric oxygen demonstrated a higher level of energy reserves (creatine phosphate, adenosine triphosphate, glycogen, and glucose) than the same muscle in room-air, control rats. The mechanisms of the beneficial effect of hyperbaric oxygen on limb survival appears to be related to preservation of high-energy phosphates and glycogen. |
| Databáze: | OpenAIRE |
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