TRAIL-based gene delivery and therapeutic strategies
| Autor: | Yongzhuo Huang, Huihai Zhong, Huiyuan Wang, Jian Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Dendrimers Combination therapy Genetic enhancement TRAIL Antineoplastic Agents Apoptosis Review Article Gene delivery Peptides Cyclic TNF-Related Apoptosis-Inducing Ligand drug delivery systems 03 medical and health sciences 0302 clinical medicine non-viral vectors Cell Line Tumor Neoplasms Bystander effect Animals Humans Medicine Pharmacology (medical) gene delivery Pharmacology business.industry Gene Transfer Techniques Drug Synergism DNA Genetic Therapy General Medicine Transfection gene therapy 030104 developmental biology 030220 oncology & carcinogenesis Liposomes Cancer cell Cancer research cancer therapy Tumor necrosis factor alpha business |
| Zdroj: | Acta Pharmacologica Sinica |
| ISSN: | 1745-7254 1671-4083 |
| Popis: | TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), also known as APO2L, belongs to the tumor necrosis factor family. By binding to the death receptor 4 (DR4) or DR5, TRAIL induces apoptosis of tumor cells without causing side toxicity in normal tissues. In recent years TRAIL-based therapy has attracted great attention for its promise of serving as a cancer drug candidate. However, the treatment efficacy of TRAIL protein was under expectation in the clinical trials because of the short half-life and the resistance of cancer cells. TRAIL gene transfection can produce a “bystander effect” of tumor cell killing and provide a potential solution to TRAIL-based cancer therapy. In this review we focus on TRAIL gene therapy and various design strategies of TRAIL DNA delivery including non-viral vectors and cell-based TRAIL therapy. In order to sensitize the tumor cells to TRAIL-induced apoptosis, combination therapy of TRAIL DNA with other drugs by the codelivery methods for yielding a synergistic antitumor efficacy is summarized. The opportunities and challenges of TRAIL-based gene delivery and therapy are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink