Assistance for Folding of Disease-Causing Plasma Membrane Proteins
| Autor: | Angelica Lopez-Rodriguez, Estela Ruiz-Baca, Karina Juarez-Navarro, Víctor M. Ayala-García, Iván Meneses-Morales, Jose Luis Rios-Banuelos |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Protein Folding lcsh:QR1-502 misrouting Review Protein aggregation Biology Biochemistry lcsh:Microbiology 03 medical and health sciences 0302 clinical medicine Protein biosynthesis Animals Humans chaperones Proteostasis Deficiencies quality control Molecular Biology proteostasis Endoplasmic reticulum Membrane Proteins Small molecule Cell biology Protein Transport 030104 developmental biology Proteostasis Membrane protein Protein folding Channelopathies Protein quality 030217 neurology & neurosurgery Molecular Chaperones |
| Zdroj: | Biomolecules Biomolecules, Vol 10, Iss 728, p 728 (2020) |
| ISSN: | 2218-273X |
| Popis: | An extensive catalog of plasma membrane (PM) protein mutations related to phenotypic diseases is associated with incorrect protein folding and/or localization. These impairments, in addition to dysfunction, frequently promote protein aggregation, which can be detrimental to cells. Here, we review PM protein processing, from protein synthesis in the endoplasmic reticulum to delivery to the PM, stressing the main repercussions of processing failures and their physiological consequences in pathologies, and we summarize the recent proposed therapeutic strategies to rescue misassembled proteins through different types of chaperones and/or small molecule drugs that safeguard protein quality control and regulate proteostasis. |
| Databáze: | OpenAIRE |
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