Targeting NF-κB c-Rel in regulatory T cells to treat corneal transplantation rejection
| Autor: | Qingguo Ruan, Hao Chi, Shaowen Wang, Songmei Zhang, Zhijiao Wu, Jiang Bian, Weiyun Shi, Tingting Fan, Xiaozhen He, Ting Wang, Jijun Sun |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Graft Rejection
medicine.medical_treatment T cell chemical and pharmacologic phenomena T-Lymphocytes Regulatory Cornea Corneal Transplantation Mice chemistry.chemical_compound Immune system Immune privilege medicine Animals Transplantation Homologous Immunology and Allergy Pharmacology (medical) Corneal transplantation Mice Inbred BALB C Transplantation Effector business.industry NF-kappa B hemic and immune systems NF-κB Allografts Mice Inbred C57BL Cytokine medicine.anatomical_structure chemistry Cancer research REL business |
| Zdroj: | American Journal of Transplantation. 21:3858-3870 |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/ajt.16760 |
| Popis: | The relevance of Tregs in the induction of tolerance against corneal allografts has been well established. Although it is well known that the conversion of Tregs into effector-like cells contributes to the loss of corneal immune privilege, the underlying mechanism is still not fully understood. Using heterologous penetrating keratoplasty model, we found that Tregs from corneal allograft rejected mice (inflam-Tregs) exhibit impaired function and characteristics of effector T cells. Further study showed that the expression of NF-κB c-Rel, a key mediator of effector T cell function, was significantly increased in inflam-Tregs. Mechanistic study revealed that elevated NF-κB c-Rel level in inflam-Tregs impaired Treg function through the promotion of inflammatory cytokine production and glycolysis. More importantly, we demonstrated that targeting NF-κB c-Rel was able to improve the immune suppressive function of inflam-Tregs in vitro and enhance the potential of them to suppress corneal transplantation rejection. Therefore, our current study identified NF-κB c-Rel as a key mediator of the conversion of Tregs into effector-like cells when under inflammatory environment. |
| Databáze: | OpenAIRE |
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