Efficacy of short-term growth hormone treatment in prepubertal children with idiopathic short stature
| Autor: | Kee Hyoung Lee, Woo Yeong Chung, Jin Soon Hwang, Byung Kyu Suh, Hyunji Ahn, Duk Hee Kim, Hyi Jeong Ji, Sei Won Yang, Cheol Woo Ko, Ho-Seong Kim, Han Wook Yoo |
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| Rok vydání: | 2013 |
| Předmět: |
Male
safety medicine.medical_specialty medicine.medical_treatment Short stature Internal medicine medicine Humans Insulin-Like Growth Factor I Adverse effect Growth Disorders child business.industry Growth factor Bone age General Medicine medicine.disease Confidence interval Idiopathic short stature Endocrinology and Metabolism short stature Endocrinology Insulin-Like Growth Factor Binding Protein 3 Treatment Outcome Growth Hormone Bone maturation idiopathic Female Original Article medicine.symptom business Hormone |
| Zdroj: | Yonsei Medical Journal |
| ISSN: | 1976-2437 |
| Popis: | Purpose: It has been reported that daily recombinant human growth hormone (GH) treatment showed beneficial effects on growth in prepubertal children with idiopathic short stature (ISS). The present study aimed to validate the GH (Eutropin ® ) effect on growth promotion and safety after short-term GH treatment. Materials and Methods: This study was an open-label, multicenter, interventional study conducted at nine university hospitals in Korea between 2008 and 2009. Thirty six prepubertal children with ISS were enrolled in this study to receive 6-month GH treatment. Yearly growth rate, height standard deviation score (SDS), and adverse events were investigated during treatment. Results: After 26 weeks of GH treatment, the height velocity significantly increased by 6.36±3.36 cm/year (p |
| Databáze: | OpenAIRE |
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