Phase II Trial of Biweekly Chemotherapy with Docetaxel and Cisplatin in High-Risk Patients with Unresectable Non-Small Cell Lung Cancer
| Autor: | Gyeong-Won Lee, Hoon Gu Kim, Ho Cheol Kim, Yi Yeong Jeong, Moon Jin Kim, Min-Gyo Kim, Yu Ji Cho, Young Sil Hwang, Seok Hyun Kim, Jung Hun Kang, Jong Duk Lee, Ja-Yoon Choi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Diarrhea
Male Oncology medicine.medical_specialty Lung Neoplasms Neutropenia Combination therapy Anemia medicine.medical_treatment Antineoplastic Agents Docetaxel Kaplan-Meier Estimate Drug Administration Schedule Carcinoma Non-Small-Cell Lung Internal medicine Drug Discovery medicine Humans Pharmacology (medical) Lung cancer Aged Neoplasm Staging Pharmacology Cisplatin Chemotherapy business.industry Combination chemotherapy General Medicine Middle Aged medicine.disease Treatment Outcome Infectious Diseases Positron-Emission Tomography Drug Therapy Combination Female Taxoids Tomography X-Ray Computed business medicine.drug |
| Zdroj: | Chemotherapy. 59:159-166 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000354983 |
| Popis: | Purpose: We investigated the efficacy and toxicity of a biweekly schedule of docetaxel and cisplatin in high-risk patients with unresectable (stages IIIB-IV) non-small cell lung cancer (NSCLC). Methods: In this study, 48 high-risk patients with previously untreated locally advanced or metastatic NSCLC were treated with combination chemotherapy consisting of docetaxel 40 mg/m2 and cisplatin 40 mg/m2; both drugs were given biweekly, on days 1 and 15, every 4 weeks in an outpatient setting. Results: Complete response, partial response, and stable disease were observed in 1 (2.1%), 30 [62.5%, 95% confidence interval (CI) 47.9-77.1], and 4 (8.3%) patients. The median overall survival was 15.1 months (95% CI 11.7-18.5) and the median time to progression was 7.5 months (95% CI 6.4-8.6). The major toxicity was grade 3 anemia in 7 (14.6%) patients. Grade 3/4 neutropenia was observed in 5 (10.4%) patients. Among the nonhematologic toxicities, grade 3 infection and grade 3 diarrhea were observed in 5 (10.4%) and 4 (8.3%) patients, respectively. No treatment-related mortality was found. Conclusions: As a front-line chemotherapy for high-risk patients with unresectable NSCLC in an outpatient setting, the biweekly schedule of docetaxel and cisplatin showed feasible efficacy with acceptable hematologic toxicities, comparable to the results of previous studies of triweekly or weekly schedules. Additional large randomized studies are needed to optimize the schedule and dosage of combination therapy with docetaxel and cisplatin in high-risk patients with unresectable NSCLC. |
| Databáze: | OpenAIRE |
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