Case Report: Severe COVID-19 Pneumonia in a Patient With Relapsed/Refractory Hodgkin’s Lymphoma
| Autor: | Sevim Tasan-Yenigun, Arif Atahan Çağatay, Selçuk Aksöz, Yusuf Bilen, Tarık Onur Tiryaki, Ipek Yonal-Hindilerden, Meliha Nalcaci, Metban Mastanzade, Fehmi Hindilerden |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty ARDS Hodgkin’s lymphoma medicine.medical_treatment Case Report donor lymphocyte infusion Hematopoietic stem cell transplantation lcsh:RC254-282 Donor lymphocyte infusion 03 medical and health sciences coronavirus disease 2019 0302 clinical medicine Internal medicine allogeneic stem cell medicine business.industry brentuximab Cancer Immunosuppression medicine.disease Hodgkin's lymphoma lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Lymphoma Pneumonia 030104 developmental biology 030220 oncology & carcinogenesis business |
| Zdroj: | Frontiers in Oncology, Vol 11 (2021) Frontiers in Oncology |
| Popis: | First identified in China in December 2019, coronavirus disease 2019 (COVID-19) has rapidly evolved into a global pandemic. The presence of haematological malignancies are expected to increase the risk of adverse outcomes from this viral infection due to the immunosuppression brought about by the underlying cancer and the effects of therapy. We present a 55-year-old woman diagnosed with relapsed/refractory Hodgkin’s lymphoma (HL) who had been heavily pretreated with multiagent chemotherapy, autologous hematopoietic stem cell transplantation (autoHCT), allogeneic hematopoietic stem cell transplantation (alloHCT) and was complicated with EBV associated posttransplant lymphoproliferative disease (PTLD) and chronic graft-versus-host-disease (GVHD). The patient was recently treated with brentuximab and donor lymphocyte infusion (DLI) for relapse after alloHCT. She suffered from severe COVID-19 pneumonia and eventually succumbed to acute respiratory distress syndrome (ARDS) and multiorgan failure. Of note, this is the first reported case of COVID-19 in a HL patient who was being treated with brentuximab for relapse after alloHCT. |
| Databáze: | OpenAIRE |
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