Regenerated cellulose micro-nano fiber matrices for transdermal drug release
| Autor: | Jonathan Y. Chen, Yuxiang Huang, Janet Zoldan, Yue Liu, Andrew Nguyen, Alicia C.B. Allen |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Biocompatibility Cell Survival Nanofibers Ionic Liquids Ibuprofen Bioengineering Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials Mice chemistry.chemical_compound X-Ray Diffraction Cell Line Tumor Spectroscopy Fourier Transform Infrared Animals Cellulose Drug Carriers Anti-Inflammatory Agents Non-Steroidal Regenerated cellulose 021001 nanoscience & nanotechnology Electrospinning 0104 chemical sciences Drug Liberation Membrane chemistry Chemical engineering Mechanics of Materials Nanofiber Thermogravimetry Drug delivery Microscopy Electron Scanning Wettability 0210 nano-technology Drug carrier |
| Zdroj: | Materials Science and Engineering: C. 74:485-492 |
| ISSN: | 0928-4931 |
| Popis: | In this work, biobased fibrous membranes with micro- and nano-fibers are fabricated for use as drug delivery carries because of their biocompatibility, eco-friendly approach, and potential for scale-up. The cellulose micro-/nano-fiber (CMF) matrices were prepared by electrospinning of pulp in an ionic liquid, 1-butyl-3-methylimidazolium chloride. A model drug, ibuprofen (IBU), was loaded on the CMF matrices by a simple immersing method. The amount of IBU loading was about 6% based on the weight of cellulose membrane. The IBU-loaded CMF matrices were characterized by Fourier-transform infrared spectroscopy, thermal gravimetric analysis, and scanning electron microscopy. The test of ibuprofen release was carried out in an acetate buffer solution of pH5.5 and examined by UV-Vis spectroscopy. Release profiles from the CMF matrices indicated that the drug release rate could be determined by a Fickian diffusion mechanism. |
| Databáze: | OpenAIRE |
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