A Different Technique to Create a ‘Myelomeningocele-Like’ Defect in the Fetal Rabbit
| Autor: | Cláudio L. Pelarigo, Rogério C. Abou-Jamra, Lilian M. Silva, Denise Araújo Lapa Pedreira, Saul Goldenberg, Paulo Roberto Valente |
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| Rok vydání: | 2002 |
| Předmět: |
Embryology
medicine.medical_specialty Meningomyelocele medicine.medical_treatment Pilot Projects Fetal position Central nervous system disease Fetus Pregnancy medicine Animals Radiology Nuclear Medicine and imaging Survival rate reproductive and urinary physiology Lagomorpha biology Fetal surgery Spina bifida business.industry Obstetrics and Gynecology General Medicine Anatomy biology.organism_classification medicine.disease Surgery Disease Models Animal Fetal Diseases Surgical Procedures Operative embryonic structures Pediatrics Perinatology and Child Health Gestation Female Rabbits business |
| Zdroj: | Fetal Diagnosis and Therapy. 17:372-376 |
| ISSN: | 1421-9964 1015-3837 |
| DOI: | 10.1159/000065388 |
| Popis: | Objective: To evaluate the fetal survival rate using a modified technique to surgically create a ‘myelomeningocele-like’ defect in a rabbit model. Methods: Six white New Zealand rabbits had a spinal defect created in their fetuses at 23 days of gestation. At 30 days of gestation, the fetuses were harvested for anatomo-pathologic evaluation. Results: The defect was created in 19 fetuses and an attempt to correct it was made in 15 cases (group I), and 4 fetuses where left without correction (group II). At 30 days, a ‘myelomeningocele-like’ defect was present in all surviving fetuses. The total survival rate was 73.68% (14/19); 11 fetus survived in group I and 3 in group II. Conclusion: The technical modifications, including fetal positioning and exposure of its back prior to the incision of the lamina, associated with a different technique for myometrium closure, offer an alternative and probably safer method to surgically create a spinal defect in the fetal rabbit. |
| Databáze: | OpenAIRE |
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