Comparison of the performance of serological kits for Helicobacter pylori infection with European and Asian study populations
| Autor: | D. C. Phung, Marta Granström, Thi Thu Ha Hoang, C. Bengtsson, Ragnar Befrits, A.-S. Rehnberg, Mikael Sörberg, T.-U. Wheeldon |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Microbiology (medical) Helicobacter pylori infection diagnosis Spirillaceae Vietnamese Immunoblotting Population Enzyme-Linked Immunosorbent Assay Sensitivity and Specificity Asymptomatic Helicobacter Infections Serology medicine Humans Commercial kits education education.field_of_study Helicobacter pylori biology business.industry General Medicine biology.organism_classification Antibodies Bacterial language.human_language Europe Infectious Diseases Vietnam Immunology language biology.protein Reagent Kits Diagnostic medicine.symptom Antibody business Sentinel Surveillance performance target populations |
| Zdroj: | Clinical Microbiology and Infection. 12:1112-1117 |
| ISSN: | 1198-743X |
| Popis: | Most commercial kits for the detection of Helicobacter pylori were developed and validated with Western populations, and some have been found to perform less well with Asian populations. This study compared the performances of three serological kits with Swedish and Vietnamese peptic ulcer patients and asymptomatic individuals. The Pyloriset EIA-GIII and HM-CAP ELISA kits indicated that Asian populations had lower antibody titres to H. pylori than European populations. Despite the difference, the Pyloriset EIA-GIII kit performed well with Vietnamese peptic ulcer patients and population controls. The HM-CAP ELISA kit had a significantly lower performance with Asian populations that could not be improved by adjustments to the cut-off level. The Helicoblot 2.1 immunoblot kit performed equally well with Vietnamese and Swedish populations, although the response rate to the 35-kDa band was significantly lower with Vietnamese individuals. |
| Databáze: | OpenAIRE |
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