The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women
| Autor: | Lawrence B. Riggs, Joseph L. Melton, William M. O'Fallon, Philip N. Sambrook, Joan M. Muhs, John A. Eisman, Kathleen S. Egan, Nigel Alexander Morrison, Tijan V. Nguyen, Paul J. Kelly |
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| Rok vydání: | 1995 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty TaqI Genotype Endocrinology Diabetes and Metabolism Minnesota Osteoporosis Molecular Sequence Data Biology Calcitriol receptor Polymerase Chain Reaction chemistry.chemical_compound Leukocyte Count Bone Density Internal medicine Genetic variation medicine Vitamin D and neurology Humans Orthopedics and Sports Medicine Allele Alleles Osteoporosis Postmenopausal Aged DNA Primers Bone mineral Analysis of Variance Polymorphism Genetic Base Sequence Middle Aged medicine.disease Endocrinology chemistry Receptors Calcitriol Female Biomarkers |
| Zdroj: | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 10(6) |
| ISSN: | 0884-0431 |
| Popis: | Bone mass and its mineral content are under genetic control. The vitamin D receptor (VDR) gene has been shown to be a major locus for genetic effects on bone mineral density (BMD), and polymorphisms in this gene accounted for a large proportion of genetic variance in BMD in an Australian population. In this study, we investigated whether similar associations are present in a North American population. We studied 139 normal healthy women (age 53.2 +/- 14.5, mean +/- SD) and 43 severely osteoporotic postmenopausal women (age 65.8 +/- 5.9). In the 127 of them with complete genetic studies, the distribution of genotypes, determined by polymerase chain reaction on leukocyte DNA samples, agreed closely with that in the Australian population. BMD was strongly related to age and weight, and, thus was adjusted for these parameters prior to genetic analysis. We found that age modulated the effect of VDR genotypes on femoral neck BMD (FN-BMD) (TaqI, p = 0.036; BsmI, p = 0.118; ApaI, p = 0.041) such that the effect of genotype was greatest among younger (premenopausal) women and declined with age so that there was no discernible difference by age 70. Among the younger women, a high FN-BMD was associated with the TT (or aa or bb) genotype while low FN-BMD was associated with the tt (or AA or BB) genotype.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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