Failure to detect amphetamine-induced dopamine release in the cortex with [11 C]FLB 457 positron emission tomography (PET): Methodological considerations
| Autor: | Rehima Jordan, Rajesh Narendran, Michael L. Himes, N. Scott Mason, Savannah Tollefson, Joshua Gertler, W. Gordon Frankle |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Pyrrolidines Article Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Dopamine Uptake Inhibitors Dopamine Internal medicine Cortex (anatomy) Salicylamides Humans Medicine Carbon Radioisotopes Amphetamine Prefrontal cortex Brain Mapping medicine.diagnostic_test business.industry Brain Binding potential Pet imaging medicine.disease 030104 developmental biology medicine.anatomical_structure Endocrinology Schizophrenia Positron emission tomography Positron-Emission Tomography Dopamine Antagonists Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Synapse. 72:e22037 |
| ISSN: | 0887-4476 |
| Popis: | Studies in nonhuman primates and humans have demonstrated that amphetamine-induced dopamine release in the cortex can be measured with [(11)C]FLB 457 and PET imaging. This technique has been successfully used in recent clinical studies to show decreased dopamine transmission in the prefrontal cortex in schizophrenia and alcohol dependence. Here, we present data from a cohort of twelve healthy controls in whom an oral amphetamine challenge (0.5 mg kg(−1)) did not lead to a significant reduction in [(11)C]FLB 457 BP(ND) (i.e., binding potential relative to non-displaceable uptake). Two factors that likely contributed to the inability to displace [(11)C]FLB 457 BP(ND) in this cohort relative to successful cohorts are: (1) the acquisition of the baseline and post-amphetamine scans on different days as opposed to the same day and (2) the initiation of the post-amphetamine [(11)C]FLB 457 scan at ~ 5 hours as opposed to ~ 3 hours following oral amphetamine. Furthermore, we show [(11)C]FLB 457 reproducibility data from a legacy dataset to support greater variability in cortical BP(ND) when the test and re-test scans are acquired on different days as compared to the same day. These results highlight the methodological challenges that continue to plague the field with respect to imaging dopamine release in the cortex. |
| Databáze: | OpenAIRE |
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