Insulin resistance and metabolic syndrome in nonobese Indian patients with non-alcoholic fatty liver disease
| Autor: | Gourdas Choudhuri, Neeraj Kumari, Ganesh Bhat, Amaresh Pandey, Chalamalasetty Sreenivasa Baba |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist India Body Mass Index Sex Factors Insulin resistance Waist–hip ratio Non-alcoholic Fatty Liver Disease Risk Factors Internal medicine medicine Humans Insulin Obesity Metabolic Syndrome business.industry Incidence Fatty liver nutritional and metabolic diseases General Medicine Overweight medicine.disease Fatty Liver Endocrinology Female Liver function Insulin Resistance Metabolic syndrome business Body mass index Follow-Up Studies |
| Zdroj: | Tropical Gastrology. 34:18-24 |
| ISSN: | 0250-636X |
| DOI: | 10.7869/tg.2012.86 |
| Popis: | BACKGROUND Insulin resistance has been recognized as a major factor in the development of non-alcoholic fatty liver disease (NAFLD). The association between insulin resistance and NAFLD, as a risk factor independent of obesity has been less well established. This study aims to determine presence of insulin resistance and components of metabolic syndrome in non-obese patients with NAFLD. METHODS 150 patients (mean age 42.25 _ 10.50 y; 115 (76%) male, 35 (24%) female) diagnosed with NAFLD participated in the study. We measured body mass index (BMI), waist circumference (WC), waist hip ratio (WHR), fasting lipid profile, fasting glucose, fasting insulin, and liver function. Insulin resistance was calculated using the homeostasis model of assessment (HOMA) formula. Insulin resistance was arbitrarily considered altered when it was >1.64. RESULTS 120 (80%) of the 150 patients were pbese (BMI >23) according to the Asia Pacific criteria. 40 (30%) had metabolic syndrome. 97.5% (117/120) had insulin resistance with mean HOMA-insulin resistance (IR) of 10.9+/-5.3. Thirty (20%) were non-obese; of these, 7 had central obesity (WC > 90 cm for men, > 80 cm for women). Twenty-three (15.3%) patients were lean NAFLD with BMI 21.6+/-1.5, WC 82.9+/-4.7 (BMI< 23, WC |
| Databáze: | OpenAIRE |
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