| Autor: |
Yu-Mu Chen, Ya-Chun Chang, Hung-Chen Chen, Tsu-Nai Wang, Wen-Feng Fang, Meng-Chih Lin, Ming-Yu Yang, Yung-Che Chen, I-Ya Chen |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of Asthma and Allergy |
| ISSN: |
1178-6965 |
| DOI: |
10.2147/jaa.s342994 |
| Popis: |
Circadian clock is synchronized to the 24-hour day by the daily light-dark cycle and proper function of circadian rhythm is essential for many physiological processes. Disruption of circadian rhythm can affect disease processes and influence disease severity, treatment responses, and even survivorship. In this retrospective case-controlled study, we tried to explore whether expression of circadian clock genes was disturbed in patients with bronchial asthma.We performed real-time quantitative reverse transcriptase-polymerase chain reactions to examine the expression of the nine core circadian clock genes (Expression levels of the nine circadian clock genes were significantly different between patients and healthy individuals, but not associated with the asthma control status. We also noted the difference ofOur results showed altered expression of circadian clock genes in patients with bronchial asthma and down-regulated |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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