Ethambutol Is Cleared by a Contemporary High-Flux Hemodialyzer, and Drug Monitoring Ensures Safety and Therapeutic Effect
| Autor: | Peter J. Donovan, Kim Ta, Brett McWhinney, Rusheng Chew, Helen Healy, Sarah Jongbloed, Jacobus P.J. Ungerer, Marion L. Woods, Dev Jegatheesan |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug Male medicine.medical_specialty Tuberculosis medicine.medical_treatment media_common.quotation_subject 030106 microbiology 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Renal Dialysis Internal medicine medicine polycyclic compounds Humans Pharmacology (medical) Ethambutol Dialysis media_common Aged Pharmacology business.industry Therapeutic effect medicine.disease bacterial infections and mycoses Surgery respiratory tract diseases Infectious Diseases Hemodialysis Drug Monitoring business 030217 neurology & neurosurgery Clearance medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 61(6) |
| ISSN: | 1098-6596 |
| Popis: | It is uncertain, given the lack of recent data and the inconclusive nature of previous data, whether ethambutol is cleared by hemodialysis using contemporary dialyzers. We measured serum ethambutol concentrations before, during, and 1 h after hemodialysis in a 75-year-old Caucasian man receiving ethambutol for disseminated Bacille Calmette-Guérin infection. There was a mean 41% decrease in serum ethambutol concentration during dialysis, confirming the hemodialyzability of ethambutol and the utility of drug monitoring in ensuring safety. |
| Databáze: | OpenAIRE |
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