Microvascular contrast enhancement in optical coherence tomography using microbubbles
| Autor: | Homa Assadi, Raffi Karshafian, I. Alex Vitkin, Alexandre Douplik, Valentin Demidov |
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| Rok vydání: | 2015 |
| Předmět: |
Materials science
Biomedical Engineering Hemodynamics 02 engineering and technology 01 natural sciences Microcirculation 010309 optics Biomaterials Speckle pattern Optics Optical coherence tomography 0103 physical sciences medicine Humans Microbubbles medicine.diagnostic_test business.industry Phantoms Imaging Blood flow 021001 nanoscience & nanotechnology Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials Flow velocity Microvessels 0210 nano-technology business Preclinical imaging Tomography Optical Coherence Biomedical engineering |
| Zdroj: | Journal of biomedical optics. 21(7) |
| ISSN: | 1560-2281 |
| Popis: | Gas microbubbles (MBs) are investigated as intravascular optical coherence tomography (OCT) contrast agents. Agar + intralipid scattering tissue phantoms with two embedded microtubes were fabricated to model vascular blood flow. One was filled with human blood, and the other with a mixture of human blood + MB. Swept-source structural and speckle variance (sv) OCT images, as well as speckle decorrelation times, were evaluated under both no-flow and varying flow conditions. Faster decorrelation times and higher structural and svOCT image contrasts were detected in the presence of MB in all experiments. The effects were largest in the svOCT imaging mode, and uniformly diminished with increasing flow velocity. These findings suggest the feasibility of utilizing MB for tissue hemodynamic investigations and for microvasculature contrast enhancement in OCT angiography. |
| Databáze: | OpenAIRE |
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