Microbiological Appraisal of Levofloxacin Activity AgainstPseudomonas aeruginosaBiofilm in Combination with Different Calcium Channel BlockersIn Vitro
| Autor: | Ayman M. Noreddin, Walid F. Elkhatib, Virginia Haynes |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Ofloxacin
medicine.drug_class Levofloxacin Microbial Sensitivity Tests Calcium channel blocker In Vitro Techniques Pharmacology medicine.disease_cause Microbiology medicine Pharmacology (medical) Antibacterial agent biology Pseudomonas aeruginosa business.industry Calcium channel Biofilm Calcium Channel Blockers biology.organism_classification Anti-Bacterial Agents Infectious Diseases Oncology Biofilms Pseudomonadales Drug Therapy Combination business Pseudomonadaceae medicine.drug |
| Zdroj: | Journal of Chemotherapy. 21:135-143 |
| ISSN: | 1973-9478 1120-009X |
| DOI: | 10.1179/joc.2009.21.2.135 |
| Popis: | Chronic multi-drug resistant Pseudomonas aeruginosa infections among hospitalized elderly patients are nearly epidemic in some institutions and biofilms are now recognized as the root cause of such chronic infections such as with cystic fibrosis patients. We address the potential risks and advantages of combining commonly prescribed calcium channel blockers (CCBs) with the fluoroquinolone levofloxacin in the treatment of P. aeruginosa biofilms by using in vitro real-time monitoring of biofilm growth/inhibition over time. while mibefradil and diltiazem appear to be strongly antagonistic toward antimicrobial activity of levofloxacin, amlodipine and bepridil appear to have significant synergistic effects. |
| Databáze: | OpenAIRE |
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