Hepato- and cardiotoxicity of Fusarium verticillioides (F. moniliforme) isolates from Southern African maize
| Autor: | N. P. J. Kriek, Walter F. O. Marasas, Pieter G. Thiel |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Fusarium
Pathology medicine.medical_specialty Cirrhosis Heart Diseases Physiology Toxicology Zea mays chemistry.chemical_compound medicine Animals Cardiotoxicity biology Mycotoxins Hyperplasia biology.organism_classification medicine.disease Thrombosis Small intestine Rats Ducks medicine.anatomical_structure chemistry Toxicity Food Microbiology Chemical and Drug Induced Liver Injury Moniliformin Cyclobutanes |
| Zdroj: | Food and Cosmetics Toxicology. 19:447-456 |
| ISSN: | 0015-6264 |
| DOI: | 10.1016/0015-6264(81)90449-1 |
| Popis: | From crops of South African and Transkeian maize were isolated 21 Fusarium verticillioides ( F. moniliforme ) strains that do not produce moniliformin, and their toxicity to ducklings and rats was determined. The pathological effects of one strain (MRC 602) were fully characterized and used as a basis for comparison with the other isolates. Acute mortality was common in ducklings fed the isolates, while in rats the mean time to death was at least 24 days even with the most toxic isolate. All the rats fed the MRC 602 isolate died, the mean times to death being 49 and 78 days, respectively, for continual intake of 32 and 16% levels of the fungal-culture material in the diet. Cirrhosis and nodular hyperplasia of the liver, and the occurrence of acute and proliferative endocardial lesions and concurrent intraventricular thrombosis were frequently encountered and were considered to be the most important lesions. Toxic nephrosis, endothelial proliferation in the pulmonary vessels, and thrombosis of the larger vessels in the heart, liver, pancreas, small intestine and lungs were considered to be less important or occurred less often. Lesions considered to be secondary to the above changes were also encountered. |
| Databáze: | OpenAIRE |
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