Potential Clinical Significance of Overall Targeting Accuracy and Motion Management in the Treatment of Tumors That Move With Respiration: Lessons Learnt From a Quarter Century of Stereotactic Body Radiotherapy From Dose Response Models
| Autor: | Sucha O. Asbell, Tamara A. LaCouture, James S. Welsh, Jimm Grimm, Ian J. Butterwick, Lawrence Kleinberg, Carla J Scofield, Alexander Muacevic, Anand Mahadevan, Kristin J. Redmond, John R. Adler, Robert A Rostock, Bahman Emami, Eric Kemmerer, Jason Stanford, Jinyu Xue, Kenneth M. Forster, Sunjay Shah |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Stereotactic body radiation therapy medicine.medical_treatment stereotactic body radiation therapy lcsh:RC254-282 Radiosurgery 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Match moving Probit model normal tissue complication probability dose response Respiration Medicine Clinical significance business.industry radiosurgery tracking lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Confidence interval Oncology 030220 oncology & carcinogenesis Toxicity Radiology Systematic Review business |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 10 (2021) |
| ISSN: | 2234-943X |
| Popis: | ObjectiveTo determine the long-term normal tissue complication probability with stereotactic body radiation therapy (SBRT) treatments for targets that move with respiration and its relation with the type of respiratory motion management (tracking vs. compression or gating).MethodsA PubMed search was performed for identifying literature regarding dose, volume, fractionation, and toxicity (grade 3 or higher) for SBRT treatments for tumors which move with respiration. From the identified papers logistic or probit dose-response models were fitted to the data using the maximum-likelihood technique and confidence intervals were based on the profile-likelihood method in the dose-volume histogram (DVH) Evaluator.ResultsPooled logistic and probit models for grade 3 or higher toxicity for aorta, chest wall, duodenum, and small bowel suggest a significant difference when live motion tracking was used for targeting tumors with move with respiration which was on the average 10 times lower, in the high dose range.ConclusionLive respiratory motion management appears to have a better toxicity outcome when treating targets which move with respiration with very steep peripheral dose gradients. This analysis is however limited by sparsity of rigorous data due to poor reporting in the literature. |
| Databáze: | OpenAIRE |
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