Prevalence of anthelmintic resistance in gastrointestinal nematodes of dairy goats under extensive management conditions in southwestern France
| Autor: | F. Soubirac, C. Couquet, J. Hubert, C. Chartier, I. Pors, Jacques Cabaret, A. Silvestre |
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| Přispěvatelé: | ProdInra, Migration, Station de Pathologie aviaire et parasitologie [Nouzilly] (PAP), Institut National de la Recherche Agronomique (INRA) |
| Rok vydání: | 2001 |
| Předmět: |
Veterinary medicine
Benzimidazole Nematoda 040301 veterinary sciences [SDV]Life Sciences [q-bio] Drug Resistance Biology 030308 mycology & parasitology 0403 veterinary science Feces 03 medical and health sciences chemistry.chemical_compound Animal science medicine Animals Anthelmintic Nematode Infections Parasite Egg Count ComputingMilieux_MISCELLANEOUS Anthelmintics 2. Zero hunger 0303 health sciences Goat Diseases Goats Fenbendazole 04 agricultural and veterinary sciences General Medicine Levamisole biology.organism_classification Teladorsagia circumcincta 3. Good health [SDV] Life Sciences [q-bio] chemistry Herd Female Animal Science and Zoology Parasitology medicine.drug Haemonchus contortus |
| Zdroj: | Journal of Helminthology Journal of Helminthology, Cambridge University Press (CUP), 2001, 75 (4), pp.325-330 |
| ISSN: | 1475-2697 0022-149X |
| DOI: | 10.1017/s0022149x01000506 |
| Popis: | The occurrence of benzimidazole (BZ) and levamisole resistance was investigated in 18 randomly selected dairy goat herds located in southwestern France and characterized by extensive management. On each of the 18 farms, 45 adult goats were randomly allocated into three groups of 15 animals each: an untreated control group, a group that was orally administered fenbendazole (10 mg kg-1 body weight) and a group that received orally a levamisole drench (12 mg kg-1 body weight). Individual faecal egg counts and pooled larval cultures were done 10 days after anthelmintic treatment. Naive lambs were infected with larvae obtained from control and fenbendazole treated groups and were necropsied 35 days after infection for worm recovery. Faecal egg count reductions (FERC) were calculated for fenbendazole and levamisole and, when less than 95 per 100, were considered as indicative of anthelmintic resistance. An in vitro egg hatch test (EHT) was conducted with thiabendazole on eggs isolated from pooled faeces of fenbendazole treated goats in nine farms. Faecal egg count reductions indicated the occurrence of benzimidazole resistance in 15 out of 18 farms. Among these farms, nine had EHT values above 0.1 μg thiabendazole ml-1 confirming the benzimidazole resistance status. Levamisole resistance was detected in two farms through FECR. Based on necropsy results, the prevalence of benzimidazole resistance was higher in Trichostrongylus colubriformis, medium in Haemonchus contortus and lower in Teladorsagia circumcincta. In nine farms the benzimidazole resistance was monospecific whereas multispecific resistance was found in the six remaining farms. A negative relationship was found between FECR for fenbendazole and the average number of anthelmintic treatments given per year on the farm. Despite extensive management including a low number of treatments, the prevalence of benzimidazole resistance was very high suggesting that the repeated and sometimes exclusive use of benzimidazole drugs, even at low frequency, is probably the main cause in developing nematode resistance in dairy goat herds. The importance of other factors such as under-dosing or buying animals already carrying resistant nematodes are discussed. |
| Databáze: | OpenAIRE |
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