Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case-control study
| Autor: | Maria Cristina Leme Godoy dos Santos, Ricardo Lehtonen Rodrigues Souza, Filipe Polese Branco, Francielle Boçon de Araujo Munhoz |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Polymorphism Single Nucleotide Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Polymorphism (computer science) Internal medicine Genotype medicine Tooth loss Humans Dental Restoration Failure Risk factor General Dentistry Aged Aged 80 and over Dental Implants business.industry Haplotype Case-control study 030206 dentistry Middle Aged Logistic Models Matrix Metalloproteinase 8 030104 developmental biology Haplotypes Case-Control Studies Female Matrix Metalloproteinase 3 Implant Gene polymorphism Matrix Metalloproteinase 1 Oral Surgery medicine.symptom business Brazil |
| Zdroj: | Clinical Implant Dentistry and Related Research. 20:1003-1008 |
| ISSN: | 1523-0899 |
| DOI: | 10.1111/cid.12671 |
| Popis: | BACKGROUND Dental implants consist in the treatment of choice to replace tooth loss. The knowledge that implant loss tends to cluster in subsets of individuals may indicate that host response is influenced by genetic factors. Matrix metalloproteinases (MMPs) are enzymes that contribute to degradation and removal of collagen from extracellular matrix. PURPOSE This case-control study aimed to investigate the haplotypic combination of MMP polymorphism (rs1144393, rs1799750, rs3025058, and rs11225395) and implant loss. MATERIALS AND METHODS Two hundred nonsmokers subjects were matched by gender, age, implant number and position and divided in control group, 100 patients with one or more healthy implants, and test group, and 100 patients with one or more implant failures. Genomic DNA was extracted from saliva and genotypes were obtained by PCR-RFLP. RESULTS A significant association of rs1799750 (MMP-1) and rs11225395 (MMP-8) polymorphism on early implant loss was demonstrated (P ≤ 0.001). Global haplotype analysis indicated a significant difference between both groups (P |
| Databáze: | OpenAIRE |
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