Anti-Inflammatory Properties of Extracts, Fractions and Lignans Isolated fromPhyllanthus amarus
| Autor: | Daniela F. P. Leite, Cândida Aparecida Leite Kassuya, Lucilia V. de Melo, João B. Calixto, Vera Lúcia Garcia Rehder |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Phyllanthus medicine.drug_class Administration Oral Pharmaceutical Science Pharmacognosy Pharmacology Carrageenan Lignans Anti-inflammatory Analytical Chemistry law.invention Mice chemistry.chemical_compound law Drug Discovery medicine Animals Edema Lignan Dose-Response Relationship Drug Platelet-activating factor biology Plant Extracts Anti-Inflammatory Agents Non-Steroidal Organic Chemistry biology.organism_classification Complementary and alternative medicine chemistry Biochemistry Molecular Medicine Phytotherapy Histamine |
| Zdroj: | Planta Medica. 71:721-726 |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | This study assessed the anti-inflammatory effect of the extracts and purified lignans obtained from Phyllanthus amarus. Given orally, the hexane extract (HE), the lignan-rich fraction (LRF), or the lignans phyltetralin, nirtetralin, niranthin, but not hypophyllanthin or phyllanthin, inhibited carrageenan (Cg)-induced paw oedema and neutrophil influx. The HE, the LRF or nirtetralin also inhibited the increase of IL1-beta tissue levels induced by Cg. Furthermore, bradykinin (BK)-, platelet activating factor (PAF)- and endothelin-1 (ET-1)-induced paw oedema were significantly inhibited by the HE or LRF while histamine- and substance P-induced paw oedema were unaffected. Finally, nirtetralin or phyltetralin caused inhibition of paw oedema induced by PAF or ET-1. These results show that the HE, the LRF and the lignans niranthin, phyltetralin and nirtetralin exhibited marked anti-inflammatory properties and suggest that these lignans seem to be the main active principles responsible for the anti-inflammatory properties reported for the HE of P. amarus. |
| Databáze: | OpenAIRE |
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