Prevention of Fog-Induced Bronchospasm by Duovent and Its Components (Fenoterol, Ipratropium Bromide) in Asthmatics
| Autor: | W. Fasano, P. Simone, Adriano Vaghi, Maria Robuschi, S. Bianco |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Adolescent Ipratropium bromide Placebo Bronchospasm chemistry.chemical_compound Time of day Bromide Forced Expiratory Volume otorhinolaryngologic diseases Humans Medicine Atropine Derivatives Fenoterol Fenoterol+ipratropium Bronchial Spasm business.industry Airway Resistance Ipratropium Humidity Middle Aged respiratory system Asthma Drug Combinations chemistry Anesthesia Female Premedication medicine.symptom business medicine.drug |
| Zdroj: | Respiration. 50:192-195 |
| ISSN: | 1423-0356 0025-7931 |
| Popis: | 16 hyperreactive asthmatics were challenged with an ultrasonic mist of H2O at the same time of day on 4 usually consecutive days 2 h after premedication with placebo, fenoterol (200 micrograms), ipratropium bromide (80 micrograms) and Duovent (fenoterol 200 micrograms + ipratropium bromide 80 micrograms), given in random order and double-blind conditions. The challenge test consisted of 3 exposures of 30, 60 and 120 s with 4-min intervals. Specific airway resistance (sRaw) was measured under basal conditions and 1, 2 and 3 min after each exposure. FEV1 was measured under basal conditions and immediately after the last sRaw measurement. Fenoterol afforded a good protection; ipratropium bromide alone was ineffective but enhanced the protective effect of fenoterol when the two drugs were given in combination (Duovent). A similar effect was also observed after a second challenge performed 1 h (9 patients) or 3 h (6 patients) after the first one, which was performed 2 h after premedication. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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