Disturbance in human gut microbiota networks by parasites and its implications in the incidence of depression
Autor: | Andrés Sánchez-Quinto, Elvia Ramírez-Carrillo, Luisa I. Falcón, Javier Nieto, Isaac González-Santoyo, Osiris Gaona, Daniel Cerqueda-García, Olga A. Rojas-Ramos |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Adult Male Adolescent lcsh:Medicine Biology Gut flora Article Microbial ecology 03 medical and health sciences Human health 0302 clinical medicine Human gut Machine learning Animals Humans lcsh:Science Ascaris lumbricoides Child Mexico Phylogeny Ascariasis Multidisciplinary Depression Incidence lcsh:R Cognition Complex network Middle Aged biology.organism_classification Bacterial host response Gastrointestinal Microbiome 030104 developmental biology Evolutionary biology Child Preschool lcsh:Q Female 030217 neurology & neurosurgery |
Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) |
ISSN: | 2045-2322 |
Popis: | If you think you are in control of your behavior, think again. Evidence suggests that behavioral modifications, as development and persistence of depression, maybe the consequence of a complex network of communication between macro and micro-organisms capable of modifying the physiological axis of the host. Some parasites cause significant nutritional deficiencies for the host and impair the effectiveness of cognitive processes such as memory, teaching or non-verbal intelligence. Bacterial communities mediate the establishment of parasites and vice versa but this complexity approach remains little explored. We study the gut microbiota-parasite interactions using novel techniques of network analysis using data of individuals from two indigenous communities in Guerrero, Mexico. Our results suggest that Ascaris lumbricoides induce a gut microbiota perturbation affecting its network properties and also subnetworks of key species related to depression, translating in a loss of emergence. Studying these network properties changes is particularly important because recent research has shown that human health is characterized by a dynamic trade-off between emergence and self-organization, called criticality. Emergence allows the systems to generate novel information meanwhile self-organization is related to the system’s order and structure. In this way, the loss of emergence means a depart from criticality and ultimately loss of health. |
Databáze: | OpenAIRE |
Externí odkaz: |