Effects of age and strain on the expression of leptin receptor, neuropeptide Y and pro-opiomelanocortin in the hypothalamus of young chickens
| Autor: | B. Liu, X.G. Luo, L. Lu, Lin Xi, J.X. Huang |
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| Rok vydání: | 2010 |
| Předmět: |
endocrine system
medicine.medical_specialty animal structures Pro-Opiomelanocortin Hypothalamus Avian Proteins Proopiomelanocortin Internal medicine medicine Animals Neuropeptide Y RNA Messenger Messenger RNA Leptin receptor Strain (chemistry) biology Leptin digestive oral and skin physiology Body Weight Age Factors General Medicine Neuropeptide Y receptor Endocrinology embryonic structures biology.protein Receptors Leptin Animal Science and Zoology Chickens hormones hormone substitutes and hormone antagonists Food Science Hormone |
| Zdroj: | British poultry science. 51(5) |
| ISSN: | 1466-1799 |
| Popis: | 1. An experiment was conducted to study changes in the expression of the hypothalamic leptin receptor, neuropeptide Y (NPY) and proopiomelanocortin (POMC) with age during the early neonatal period in two different strains of chickens: Beijing-You (BY) and Arbor Acres (AA). 2. Compared with BY chickens, AA chickens ate more, and grew faster. Hypothalamic NPY concentrations of both strains increased with age until d 7 followed by a decline. Hypothalamic NPY of BY chickens on d 7 was lower than in AA chickens at the same age. 3. No difference with age was observed in hypothalamic α-melanocyte-stimulating hormone (α-MSH) of BY chickens, while hypothalamic α-MSH in AA chickens on d 0 was higher than on the other days. Compared with AA chickens, BY chickens showed lower hypothalamic α-MSH on d 0. 4. Similar developmental changes between two strains were observed in the expression of leptin receptor, NPY or POMC genes in the hypothalamus. Hypothalamic mRNA of leptin receptor on d 0 was higher than on d 1 and 7. Unlike NPY, hypothalamic NPY mRNA on d 0 was higher than on the other days. 5. Hypothalamic POMC mRNA decreased gradually with age until 7 d followed by a slight increase. 6. The results showed that the developmental changes of hypothalamic signal molecules varied with age and strain. NPY, α-MSH and leptin receptor might be involved in the early programming of feed intake in newly hatched chickens. |
| Databáze: | OpenAIRE |
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