Feasibility of Intravoxel Incoherent Motion for Differentiating Benign and Malignant Thyroid Nodules
| Autor: | Yi ling Zhao, Hui Tan, Liang Zhang, Jin huan Liu, Dongjie Huang, Jun Chen, Chang sheng Liu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Thyroid nodules
Adult Male Thyroid Gland Sensitivity and Specificity 030218 nuclear medicine & medical imaging Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Independent samples Preoperative Care medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Thyroid Nodule Intravoxel incoherent motion medicine.diagnostic_test business.industry Magnetic resonance imaging Middle Aged medicine.disease Image Enhancement Diffusion Magnetic Resonance Imaging 030220 oncology & carcinogenesis Feasibility Studies Female Differential diagnosis Nuclear medicine business |
| Zdroj: | Academic radiology. 26(2) |
| ISSN: | 1878-4046 |
| Popis: | This study aimed to preliminarily investigate the feasibility of intravoxel incoherent motion (IVIM) theory in the differential diagnosis of benign and malignant thyroid nodules.Forty-five patients with 56 confirmed thyroid nodules underwent preoperative routine magnetic resonance imaging and IVIM diffusion-weighted imaging. The histopathologic diagnosis was confirmed by surgery. Apparent diffusion coefficient (ADC), perfusion fraction f, diffusivity D, and pseudo-diffusivity D* were quantified. Independent samples t test of IVIM-derived metrics were conducted between benign and malignant nodules. Receiver-operating characteristic analyses were performed to determine the optimal thresholds as well as the sensitivity and specificity for differentiating.Significant intergroup difference was observed in ADC, D, D*, and f (p0.001). Malignant tumors featured significantly lower ADC, D and D* values and a higher f value than that of benign nodules. The ADC, D, and D* could distinguish the benign from malignant thyroid nodules, and parameter f differentiate the malignant tumors from benign nodules. The values of the area under the curve for parameter ADC, D, and D* were 0.784 (p = 0.001), 0.795 (p = 0.001), and 0.850 (p0.001), separately, of which the area under the curve of f value was the maximum for identifying the malignant from benign nodules, which was 0.841 (p0.001).This study suggested that ADC and IVIM-derived metrics, including D, D*, and f, could potentially serve as noninvasive predictors for the preoperative differentiating of thyroid nodules, and f value performed best in identifying the malignant from benign nodules among these parameters. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|