Fractional Exhaled Nitric Oxide in Healthy Tibetans at High Altitude
| Autor: | Xuewen Ren, Tan-shi Li, Chunyan Man, Heng Hong, Gang Zhao, Li Chen, Hao Wang, Huai-Yu Qiao |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Nitric Oxide Synthase Type III Adolescent Altitude Sickness Tibet Nitric Oxide Altitude Animal science Clinical Research Medicine Humans Han population Aged business.industry Airway inflammation Exhalation General Medicine Effects of high altitude on humans respiratory system Middle Aged respiratory tract diseases Breath Tests Health Exhaled nitric oxide Immunology Multiple linear regression analysis Female Geometric mean business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | Background Fractional exhaled NO (FENO) is a marker of airway inflammation. For successful use of this marker it is important to have reference ranges from different healthy populations. The aim of this study was to establish these in healthy Tibetan adults who had always lived at high altitude on the Qinghai-Tibet Plateau. Material and methods The study included 145 healthy Tibetan subjects, aged 18 to 75 years, who were non-smokers. FENO was measured at a flow rate of 50 mL/s using a chemiluminescence analyzer. Residential altitude was classified as: Grade 1 (3678-3800 m), Grade 2 (3800-4200 m), or Grade 3 (>4200 m). Correlations between subject characteristics (age, sex, height, and weight), altitude, and FENO were investigated. Results The geometric mean FENO (95% CI) was 15.4 (7.0, 35.0) parts per billion (ppb). The 95% upper limit of the log-transformed data was 33.0 ppb, which was slightly lower than that for Han Chinese, and much lower than in the Northwest Han population. Mean FENO values were higher in males (16.8 ppb) than females (14.3 ppb) and inversely related to altitude. Multiple linear regression analysis showed that FENO was predicted by the equation Ln (FENO)=[2.844+0.161 × sex (1 for male; 0 for female) -0.111 × altitude grade]. The residual standard deviation (SD) was 0.048, and the explanatory value was 7%. Conclusions The upper limit of FENO in healthy Tibetan adults is 33 ppb. This value can be predicted on the basis of sex and altitude. |
| Databáze: | OpenAIRE |
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