Frontopolar cortex activation associated with pessimistic future-thinking in adults with major depressive disorder
| Autor: | Yuri Terasawa, Atsuo Nakagawa, Toshiaki Kikuchi, Masaru Mimura, Hajime Tabuchi, Nariko Katayama, Satoshi Umeda, Chika Kurata |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Brain activity and meditation Cognitive Neuroscience Prefrontal Cortex Brodmann area 10 lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Neuroimaging Neural Pathways medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Cognitive skill lcsh:Neurology. Diseases of the nervous system Depressive Disorder Major Recall 05 social sciences Cognition Regular Article Middle Aged medicine.disease Magnetic Resonance Imaging Pessimism Neurology Major depressive disorder lcsh:R858-859.7 Female Neurology (clinical) Psychology 030217 neurology & neurosurgery Clinical psychology Brodmann area |
| Zdroj: | NeuroImage: Clinical, Vol 23, Iss, Pp-(2019) |
| Popis: | Background: Pessimistic thinking about the future is one of the cardinal symptoms of major depressive disorder (MDD) and is an important domain of cognitive functioning associated with hopelessness. Neuroimaging studies have shown that the frontopolar cortex (Brodmann area [BA] 10) is involved in thinking about the future and demonstrated that patients with MDD have dysfunctions in BA10. However, the relationship between pessimistic thinking about the future and brain activity is unclear. Hence, we aimed to compare brain activity during future-thinking between patients with MDD and healthy individuals. Methods: We assessed 23 patients with current MDD and 23 healthy individuals. Participants were instructed to imagine the future or to recall the past using the future-thinking paradigm with four distinct temporal conditions (distant future, near future, distant past, and near past) during functional MRI. Resting-state functional MRI was also performed to explore the functional connectivity of BA10. Results: Compared with healthy individuals, patients with MDD had greater negative thinking about the distant future and exhibited increased activation in the medial BA10 when imagining the distant future, following small-volume correction focusing on the frontopolar a priori region of interest (family-wise error correction p |
| Databáze: | OpenAIRE |
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