| Autor: |
Doddabasappa Talimarada, Akanksha Sharma, Harish Holla |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of biomolecular structuredynamics. |
| ISSN: |
1538-0254 |
| Popis: |
The drugs prescribed for targeting the tumour growth comprise of chemotherapy regimen involving combinations to cell-cycle phase specific target receptors. The combination therapy with Topoisomerase-I (Topo-I)anti-tubulin agents are in the clinical trial stages and have scope for identifying new chemical entities with dual binding and inhibiting potential. The checkpoint proteins present at the interface of cell-cycle phases are considered the link between these two that establish the connectivity across the two phases of cell-cycle. In the present study, this potential cross-link or dual targeting is explored via |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
