Response assessment of colorectal liver metastases with contrast enhanced CT/18F-FDG PET
| Autor: | Maria Dolores Pineda Pineda, Ceferino Molino Trinidad, Victoria Sánchez Pérez, Esther Domínguez Ferreras, Víctor Manuel Poblete García, Fátima Jiménez Aragón, Ángel Soriano Castrejón, José Carlos Villa Guzmán, Ana María García Vicente |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Treatment response medicine.medical_specialty Enhanced ct Colorectal cancer medicine.medical_treatment Contrast Media Multimodal Imaging Sensitivity and Specificity 18f fdg pet Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging Aged Chemotherapy business.industry Liver Neoplasms Reproducibility of Results General Medicine Middle Aged Image Enhancement medicine.disease Iopamidol Response assessment Clinical trial Treatment Outcome Spain Positron-Emission Tomography Female Histopathology Radiology Radiopharmaceuticals Colorectal Neoplasms Tomography X-Ray Computed business |
| Zdroj: | European Journal of Radiology. 82:e255-e261 |
| ISSN: | 0720-048X |
| Popis: | Purpose Evaluate the diagnostic performance of contrast enhanced CT/PET (ceCT/PET) in the response assessment of patients with colorectal cancer liver metastases. Methods 33 ce CT/PET studies of 19 patients with colorectal liver metastases were prospectively evaluated. All of them, 13 (68.4%) were males and 6 (31.6%) females. Mean age and range were 63 [42–78]. All patients were treated with neoadjuvant chemotherapy. In all cases post-therapy diagnostic confirmation of liver lesions was obtained. A ce CT PET/was obtained 1 h after the injection of 370 MBq of 18F-FDG. Metabolic and morphologic studies were evaluated by two blinded nuclear physicians and radiologists respectively to assess the location, size and suspected diagnosis of lesions (benign or malignant). A combined assessment of both techniques was performed. The final diagnosis was established by histopathology or clinical/radiological follow-up greater than 6 months. Results A total of 120 liver lesions were identified, 115 were malignant and 5 benign. From the malignant lesions, 105 were identified with the ceCT, 44 with the PET and 109 with ceCT/PET. All of the benign lesions were correctly classified with any of the three imaging techniques. The sensitivity of PET, ceCT and ceCT/PET were of 38%, 91% and 95% respectively and the specificity was 100% in all three of the diagnostic studies. Conclusion Administration of intravenous contrast in the PET/CT is mandatory to evaluate treatment response rate of liver metastases due to the limitations of isolated metabolic images in these cases. |
| Databáze: | OpenAIRE |
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