The Risk of Osteoporosis and Osteoporotic Fracture Following the Use of Irritable Bowel Syndrome Medical Treatment: An Analysis Using the OMOP CDM Database

Autor:	Jeong Gyu Lee, Youngin Lee, Jin-Mi Kim, Young Min Park, Gyu Lee Kim, Sang Yeoup Lee, Eun Ju Park, Youn Hye Cho, Yu Hyeon Yi, Seunghun Lee, Yun Jin Kim, Hye Rim Hwang, Young Jin Tak
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Osteoporosis 030209 endocrinology & metabolism computer.software_genre Article 03 medical and health sciences 0302 clinical medicine treatment for IBS medicine Osteoporotic fracture Irritable bowel syndrome irritable bowel syndrome Database Medical treatment business.industry Incidence (epidemiology) Hazard ratio General Medicine medicine.disease osteoporosis Confidence interval Medicine 030211 gastroenterology & hepatology Observational study business computer
Zdroj:	Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 2044, p 2044 (2021) Volume 10 Issue 9
ISSN:	2077-0383
Popis:	Patients with irritable bowel syndrome (IBS) are at increased risk of osteoporosis and osteoporotic fracture. This study investigated whether IBS medication attenuated the rate of osteoporosis and osteoporotic fracture risk. We conducted a retrospective large-scale multicenter study across eight hospital databases encoded in the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). The primary outcome was the incidence of osteoporosis, whereas secondary outcomes were osteoporotic fractures. After 1:4 matching, 24,723 IBS patients, 78,318 non-IBS patients, 427,640 non-IBS patients with IBS medication, and 827,954 non-IBS patients without IBS medication were selected. The risk of osteoporosis was significantly increased in the IBS group compared to the non-IBS group (hazard ratio (HR) 1.33 confidence interval (CI) 1.17~1.51). Even in patients who were not diagnosed with IBS, the risk of osteoporosis was significantly increased in those with IBS medication compared to those without (HR 1.77, CI 1.62~1.93). The risk of osteoporotic fracture was significantly increased in the IBS medication group (HR 1.69, CI 1.55~1.84). Patients exposed to IBS treatment even without IBS diagnosis were at increased risk of osteoporosis and osteoporotic fracture. Early diagnosis and treatment of osteoporosis should be considered in patients who have received medication for IBS symptoms.
Databáze:	OpenAIRE
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