Infection with respiratory syncytial virus enhances expression of native receptors for non-pilateNeisseria meningitidison HEp-2 cells
| Autor: | Omar R. El Ahmer, Robert A. Elton, Muhammad W. Raza, Abdulrahman T. Saadi, Donald M. Weir, Marie Ogilvie, C. Caroline Blackwell |
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| Rok vydání: | 1999 |
| Předmět: |
Lipopolysaccharides
Microbiology (medical) Erythrocytes Paramyxoviridae Immunology Lipopolysaccharide Receptors Lewis X Antigen Neisseria meningitidis Biology medicine.disease_cause Microbiology Bacterial Adhesion Virus Viral Proteins Viral Envelope Proteins Antigen Antigens CD Streptococcus pneumoniae Cell Adhesion Tumor Cells Cultured medicine Animals Humans Immunology and Allergy Adhesins Bacterial Mononegavirales HN Protein Sheep Antibodies Monoclonal Epithelial Cells General Medicine biology.organism_classification Virology Respiratory Syncytial Viruses Up-Regulation Infectious Diseases Cell culture CD18 Antigens Respiratory virus |
| Zdroj: | FEMS Immunology & Medical Microbiology. 23:115-124 |
| ISSN: | 1574-695X 0928-8244 |
| DOI: | 10.1111/j.1574-695x.1999.tb01230.x |
| Popis: | Respiratory virus infections have been suggested to be predisposing factors for meningococcal disease. Respiratory syncytial virus (RSV) affects young children in the age range at greatest risk of disease caused by Neisseria meningitidis. It has been previously shown that glycoprotein G expressed on the surface of RSV-infected HEp-2 cells (a human epithelial cell line) contributed to higher levels of binding of meningococci compared with uninfected cells. The aim of the present study was to examine the effect of RSV infection on expression of surface molecules native to HEp-2 cells and their role in bacterial binding. Flow cytometry and fluorescence microscopy were used to assess bacterial binding and expression of host cell antigens. Some molecules analysed in this study have not been reported previously on epithelial cells. RSV infection significantly enhanced the expression of CD15 (P |
| Databáze: | OpenAIRE |
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