Fine-needle aspiration for diagnosis of tuberculous lymphadenitis in children in Bangui, Central African Republic

Autor: Germain Zandanga, Minime-Lingoupou Fanny, F Yango, Leen Rigouts, Narcisse Beyam, Catherine Pierre-Audigier, Brigitte Gicquel, Jean Chrusostome Gody, Gustave Bobossi, Alexandre Manirakiza
Přispěvatelé: Mycobactéries, Institut Pasteur de Bangui, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Hôpital pédiatrique de Bangui, Mycobacteriology Unit, Institute of Tropical Medicine [Antwerp] (ITM), Génétique mycobactérienne - Mycobacterial genetics, Institut Pasteur [Paris], Institut Pasteur [Paris] (IP)
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
Antitubercular Agents
Drug resistance
Tuberculosis
Lymph Node
Fine needle aspiration
0302 clinical medicine
Diagnosis
030212 general & internal medicine
Prospective Studies
Child
medicine.diagnostic_test
biology
Isoniazid
lcsh:RJ1-570
Tuberculous lymphadenitis
3. Good health
Central African Republic
Fine-needle aspiration
030220 oncology & carcinogenesis
Child
Preschool
Female
medicine.drug
Research Article
medicine.medical_specialty
Tuberculosis
Adolescent
Biopsy
Fine-Needle
Microbial Sensitivity Tests
Mycobacterium tuberculosis
03 medical and health sciences
Lymphadenitis
Internal medicine
medicine
Humans
Pediatrics
Perinatology
and Child Health
Ethambutol
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
business.industry
Infant
Newborn
Infant
lcsh:Pediatrics
medicine.disease
biology.organism_classification
Surgery
Pediatrics
Perinatology and Child Health
Axilla
Lymph Nodes
Human medicine
business
Rifampicin
Neck
Zdroj: BMC pediatrics
BMC Pediatrics, Vol 12, Iss 1, p 191 (2012)
BMC Pediatrics
BMC Pediatrics, BioMed Central, 2012, 12 (1), pp.191. ⟨10.1186/1471-2431-12-191⟩
BMC Pediatrics, 2012, 12 (1), pp.191. ⟨10.1186/1471-2431-12-191⟩
ISSN: 1471-2431
Popis: Background Tuberculosis (TB) is a major cause of childhood morbidity and mortality in developing countries. One of the main difficulties is obtaining adequate specimens for bacteriological confirmation of the disease in children. The aim of this study is to evaluate the adequacy of fine-needle aspiration (FNA) for the diagnosis of TB. Methods In a prospective study conducted at the paediatric hospital in Bangui in 2007–2009, we used fine-needle aspiration to obtain samples for diagnosis of TB from 131 children aged 0–17 years with persistent lymphadenitis. Results Fine-needle aspiration provided samples that could be used for bacteriological confirmation of TB. Ziehl-Neelsen staining for acid-fast bacilli was positive in 42.7% of samples, and culture identified TB in 67.2% of cases. Of 75 samples that were stain-negative, 49 (65.3%) were culture-positive, while 12 stain-positive samples remained culture-negative. Ten of the 12 stain-positive, culture-negative samples were from patients who had received previous antimicrobial therapy. With regard to phenotypic drug susceptibility, 81/88 strains (91.1%) were fully susceptible to isoniazid, rifampicin, ethambutol and streptomycin, six (6.8%) were resistant to one drug, and one multidrug-resistant strain was found. Conclusions Fine-needle aspiration is simple, cost-effective and non-invasive and can be performed by trained staff. Combined with rapid molecular diagnostic tests, fine-needle aspirates could improve the diagnosis of TB and provide valuable information for appropriate treatment and drug resistance.
Databáze: OpenAIRE
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