Prevalence, risk factors, and impact on outcome of cytomegalovirus replication in serum of Cambodian HIV-infected patients (2004-2007)
| Autor: | Marianne Leruez-Ville, Hak Chanroeun, Veasna Duong, Philippe J Guerin, Philippe Buchy, Suna Balkan, Jean-Philippe Dousset, Laurent Ferradini, Arnaud Fontanet, Julie Galimand, Romain Micol, Christine Rouzioux, Gilles Guerrier, Olivier Lortholary |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Opportunistic infection Congenital cytomegalovirus infection Prevalence Cytomegalovirus HIV Infections Virus Replication Gastroenterology Betaherpesvirinae Risk Factors Internal medicine Antiretroviral Therapy Highly Active medicine Humans Pharmacology (medical) Risk factor biology business.industry virus diseases biology.organism_classification medicine.disease CD4 Lymphocyte Count Infectious Diseases Immunology DNA Viral Coinfection Female Viral disease business Cambodia Viral load |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999). 51(4) |
| ISSN: | 1525-4135 |
| Popis: | Background: In developing countries, the study of cytomegalovirus (CMV) coinfection in HIV-infected patients remains neglected. Quantitative CMV polymerase chain reaction (PCR) is the gold standard diagnostic tool for analyzing serum CMV replication and for predicting CMV disease. We estimated the prevalence of replicating CMV in sera of newly diagnosed HIV-infected Cambodian patients and examined its impact on mortality. Methods: This cohort study was based on 2 highly active antiretroviral therapy treatment programs in Cambodia between 2004 and 2007. Quantitative CMV PCR was performed on baseline serum samples of 377 HIV-infected patients. Results: The prevalence of serum CMV DNA was 55.2% (150 of 272) in patients with CD4 + count |
| Databáze: | OpenAIRE |
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